Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 12% | |
GABAergic neuron | 9 studies | 41% ± 23% | |
glutamatergic neuron | 9 studies | 40% ± 25% | |
fibroblast | 9 studies | 22% ± 7% | |
oligodendrocyte precursor cell | 8 studies | 29% ± 14% | |
astrocyte | 8 studies | 31% ± 17% | |
epithelial cell | 7 studies | 33% ± 12% | |
microglial cell | 7 studies | 25% ± 8% | |
non-classical monocyte | 6 studies | 21% ± 6% | |
interneuron | 6 studies | 51% ± 21% | |
macrophage | 6 studies | 35% ± 8% | |
myeloid cell | 6 studies | 24% ± 6% | |
oligodendrocyte | 6 studies | 29% ± 10% | |
dendritic cell | 5 studies | 26% ± 11% | |
smooth muscle cell | 5 studies | 22% ± 5% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 4% | |
hematopoietic precursor cell | 4 studies | 24% ± 8% | |
classical monocyte | 4 studies | 22% ± 6% | |
neuron | 4 studies | 34% ± 9% | |
granule cell | 4 studies | 22% ± 5% | |
retinal ganglion cell | 4 studies | 26% ± 5% | |
B cell | 4 studies | 21% ± 4% | |
adipocyte | 4 studies | 20% ± 3% | |
cardiac muscle cell | 4 studies | 24% ± 2% | |
mast cell | 4 studies | 20% ± 3% | |
lymphocyte | 4 studies | 22% ± 4% | |
basal cell | 4 studies | 27% ± 13% | |
monocyte | 4 studies | 24% ± 4% | |
natural killer cell | 3 studies | 17% ± 1% | |
GABAergic interneuron | 3 studies | 40% ± 5% | |
ciliated cell | 3 studies | 24% ± 3% | |
OFF-bipolar cell | 3 studies | 20% ± 5% | |
ON-bipolar cell | 3 studies | 24% ± 6% | |
endothelial cell of vascular tree | 3 studies | 24% ± 7% | |
alveolar macrophage | 3 studies | 26% ± 9% | |
pericyte | 3 studies | 22% ± 6% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2666.98 | 459 / 459 | 99% | 11.64 | 1107 / 1118 |
esophagus | 100% | 1935.43 | 1445 / 1445 | 99% | 9.45 | 181 / 183 |
lung | 99% | 2139.14 | 572 / 578 | 99% | 7.15 | 1148 / 1155 |
thymus | 100% | 2834.22 | 653 / 653 | 98% | 7.32 | 595 / 605 |
stomach | 100% | 2116.57 | 359 / 359 | 98% | 8.27 | 279 / 286 |
brain | 98% | 1924.33 | 2598 / 2642 | 99% | 6.84 | 699 / 705 |
uterus | 100% | 2898.60 | 170 / 170 | 97% | 6.83 | 446 / 459 |
kidney | 100% | 1825.29 | 89 / 89 | 97% | 9.21 | 875 / 901 |
pancreas | 100% | 1930.30 | 327 / 328 | 97% | 6.40 | 173 / 178 |
bladder | 100% | 2363.24 | 21 / 21 | 97% | 6.54 | 487 / 504 |
ovary | 100% | 3360.36 | 180 / 180 | 96% | 5.38 | 414 / 430 |
prostate | 100% | 2312.98 | 245 / 245 | 96% | 7.29 | 483 / 502 |
adrenal gland | 100% | 2574.38 | 258 / 258 | 96% | 6.31 | 220 / 230 |
intestine | 100% | 2577.79 | 966 / 966 | 96% | 7.45 | 504 / 527 |
skin | 100% | 2576.11 | 1806 / 1809 | 91% | 9.87 | 431 / 472 |
liver | 100% | 1498.12 | 226 / 226 | 85% | 4.31 | 347 / 406 |
blood vessel | 100% | 3434.04 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2764.85 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2469.50 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 1730.95 | 838 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 8.67 | 28 / 29 |
tonsil | 0% | 0 | 0 / 0 | 93% | 7.35 | 42 / 45 |
peripheral blood | 77% | 1800.20 | 718 / 929 | 0% | 0 | 0 / 0 |
muscle | 66% | 414.34 | 527 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 61% | 3.92 | 49 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006020 | Biological process | inositol metabolic process |
GO_0007605 | Biological process | sensory perception of sound |
GO_0043647 | Biological process | inositol phosphate metabolic process |
GO_0032958 | Biological process | inositol phosphate biosynthetic process |
GO_0005829 | Cellular component | cytosol |
GO_0000832 | Molecular function | inositol hexakisphosphate 5-kinase activity |
GO_0052724 | Molecular function | inositol hexakisphosphate 3-kinase activity |
GO_0000829 | Molecular function | inositol heptakisphosphate kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0000828 | Molecular function | inositol hexakisphosphate kinase activity |
GO_0052723 | Molecular function | inositol hexakisphosphate 1-kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0033857 | Molecular function | diphosphoinositol-pentakisphosphate kinase activity |
GO_0000827 | Molecular function | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
Gene name | PPIP5K2 |
Protein name | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2) Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) Diphosphoinositol pentakisphosphate kinase 2 |
Synonyms | VIP2 KIAA0433 HISPPD1 |
Description | FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 . PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation . Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 . Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 . Required for normal hearing . . FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). . FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). . FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). . FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). . |
Accessions | A0A087WWN8 K7EPT7 K7ENU7 D6RBU4 ENST00000507921.5 ENST00000321521.13 [O43314-2] ENST00000511022.2 ENST00000358359.8 [O43314-1] A0A8V8TMN4 ENST00000627916.2 ENST00000414217.5 [O43314-2] ENST00000698750.1 ENST00000502481.5 ENST00000507310.1 H0Y9M0 O43314 ENST00000613907.4 K7EJG8 ENST00000504275.1 H0Y9S9 ENST00000515845.5 D6RFG4 ENST00000613674.4 A0A087WZV0 ENST00000509597.5 |