PPIP5K2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006020Biological processinositol metabolic process
GO_0007605Biological processsensory perception of sound
GO_0043647Biological processinositol phosphate metabolic process
GO_0032958Biological processinositol phosphate biosynthetic process
GO_0005829Cellular componentcytosol
GO_0000832Molecular functioninositol hexakisphosphate 5-kinase activity
GO_0052724Molecular functioninositol hexakisphosphate 3-kinase activity
GO_0000829Molecular functioninositol heptakisphosphate kinase activity
GO_0005524Molecular functionATP binding
GO_0000828Molecular functioninositol hexakisphosphate kinase activity
GO_0052723Molecular functioninositol hexakisphosphate 1-kinase activity
GO_0005515Molecular functionprotein binding
GO_0033857Molecular functiondiphosphoinositol-pentakisphosphate kinase activity
GO_0000827Molecular functioninositol-1,3,4,5,6-pentakisphosphate kinase activity

IV. Literature review

[source]
Gene namePPIP5K2
Protein nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24)
Diphosphoinositol pentakisphosphate kinase 2
SynonymsVIP2
KIAA0433
HISPPD1
DescriptionFUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 . PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation . Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 . Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 . Required for normal hearing . .

FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). .

FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). .

FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). .

FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6). .

AccessionsA0A087WWN8
K7EPT7
K7ENU7
D6RBU4
ENST00000507921.5
ENST00000321521.13 [O43314-2]
ENST00000511022.2
ENST00000358359.8 [O43314-1]
A0A8V8TMN4
ENST00000627916.2
ENST00000414217.5 [O43314-2]
ENST00000698750.1
ENST00000502481.5
ENST00000507310.1
H0Y9M0
O43314
ENST00000613907.4
K7EJG8
ENST00000504275.1
H0Y9S9
ENST00000515845.5
D6RFG4
ENST00000613674.4
A0A087WZV0
ENST00000509597.5