PPFIA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099519Biological processdense core granule cytoskeletal transport
GO_0007160Biological processcell-matrix adhesion
GO_0060998Biological processregulation of dendritic spine development
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0099172Biological processpresynapse organization
GO_0050808Biological processsynapse organization
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0098978Cellular componentglutamatergic synapse
GO_0043197Cellular componentdendritic spine
GO_0070062Cellular componentextracellular exosome
GO_0042734Cellular componentpresynaptic membrane
GO_0009986Cellular componentcell surface
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0005737Cellular componentcytoplasm
GO_0099572Cellular componentpostsynaptic specialization
GO_0030424Cellular componentaxon
GO_0099181Molecular functionstructural constituent of presynapse
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPFIA2
Protein nameLiprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)
PTPRF interacting protein alpha 2
PPFIA2 variant protein
Synonymsprotein
variant
DescriptionFUNCTION: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines . .

AccessionsENST00000551147.1
H0YIJ4
ENST00000443686.7 [O75334-6]
ENST00000548586.5 [O75334-3]
ENST00000541570.6 [O75334-7]
ENST00000548670.1
ENST00000552948.5 [O75334-4]
H0YHJ4
ENST00000547623.5
ENST00000550359.6
ENST00000407050.8 [O75334-5]
ENST00000550584.6
Q4LE62
ENST00000549396.6 [O75334-1]
H0YHK3
ENST00000549325.5 [O75334-2]
F8VWG6
F8VWR9
ENST00000553058.5
H0YH95
ENST00000550018.5
ENST00000541017.5 [O75334-8]
O75334
F8W1Y8
G3V200
F8VU88
ENST00000551461.5
F8VYK7
ENST00000333447.11 [O75334-6]
ENST00000551442.5
ENST00000548790.1