POU4F3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POU4F3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU4F3 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0007605Biological processsensory perception of sound
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0042491Biological processinner ear auditory receptor cell differentiation
GO_0050885Biological processneuromuscular process controlling balance
GO_0051402Biological processneuron apoptotic process
GO_0042472Biological processinner ear morphogenesis
GO_0048675Biological processaxon extension
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0021562Biological processvestibulocochlear nerve development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOU4F3
Protein namePOU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)
SynonymsBRN3C
DescriptionFUNCTION: Acts as a transcriptional activator . Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes . Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). .

AccessionsQ15319
ENST00000646991.2