PORCN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PORCN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PORCN at tissue level.

III. Associated gene sets

GO_0016055Biological processWnt signaling pathway
GO_0018345Biological processprotein palmitoylation
GO_0061355Biological processWnt protein secretion
GO_0030258Biological processlipid modification
GO_0009100Biological processglycoprotein metabolic process
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0045234Biological processprotein palmitoleylation
GO_0006497Biological processprotein lipidation
GO_0098978Cellular componentglutamatergic synapse
GO_0005783Cellular componentendoplasmic reticulum
GO_0032281Cellular componentAMPA glutamate receptor complex
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0017147Molecular functionWnt-protein binding
GO_1990698Molecular functionpalmitoleoyltransferase activity

IV. Literature review

[source]
Gene namePORCN
Protein namePorcupine O-acyltransferase
Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.250) (Protein MG61)
SynonymsMG61
PPN
PORC
DescriptionFUNCTION: Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. .

AccessionsENST00000683923.1 [Q9H237-4]
ENST00000359882.8 [Q9H237-3]
ENST00000485288.7
ENST00000361988.7 [Q9H237-4]
ENST00000367574.9 [Q9H237-4]
F2Z360
ENST00000326194.11 [Q9H237-1]
ENST00000355961.8 [Q9H237-2]
ENST00000489940.5
ENST00000472520.5
Q9H237
ENST00000537758.6 [Q9H237-4]
F8WEW7
ENST00000528612.5
C9JWI5