POLR3K report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLR3K at tissue level.

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0006386Biological processtermination of RNA polymerase III transcription
GO_0006383Biological processtranscription by RNA polymerase III
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex
GO_0001056Molecular functionRNA polymerase III activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003676Molecular functionnucleic acid binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR3K
Protein nameAlternative protein POLR3K
DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)
SynonymsRPC11
My010
DescriptionFUNCTION: Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates . Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination (By similarity). Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway . .

AccessionsL0R6M6
Q9Y2Y1
ENST00000293860.6