POLR3H report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006384Biological processtranscription initiation at RNA polymerase III promoter
GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0051607Biological processdefense response to virus
GO_0006383Biological processtranscription by RNA polymerase III
GO_0045087Biological processinnate immune response
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005666Cellular componentRNA polymerase III complex
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR3H
Protein nameDNA-directed RNA polymerase subunit
RNA polymerase III subunit H
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)
SynonymsRPC8
KIAA1665
DescriptionFUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway . .

FUNCTION: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

FUNCTION: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

AccessionsENST00000432789.1
ENST00000337566.9 [Q9Y535-2]
ENST00000396504.6 [Q9Y535-1]
ENST00000407461.5 [Q9Y535-1]
ENST00000355209.9 [Q9Y535-1]
F8WDV1
Q9Y535
F8WDS5
ENST00000442616.1
ENST00000431534.5
E7ERZ2