POLR3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032728Biological processpositive regulation of interferon-beta production
GO_0042797Biological processtRNA transcription by RNA polymerase III
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0006351Biological processDNA-templated transcription
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005666Cellular componentRNA polymerase III complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0001056Molecular functionRNA polymerase III activity
GO_0003682Molecular functionchromatin binding
GO_0000287Molecular functionmagnesium ion binding
GO_0071667Molecular functionDNA/RNA hybrid binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene namePOLR3A
Protein nameDNA-directed RNA polymerase subunit (EC 2.7.7.6)
DNA-directed RNA polymerase (EC 2.7.7.6)
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
Synonyms
DescriptionFUNCTION: Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci . Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA . Forms Pol III active center together with the second largest subunit POLR3B/RPC2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate . Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. .

AccessionsA0A8V8TNL6
A0A8V8TNX3
ENST00000473588.2
ENST00000372371.8
A0A8V8TM36
ENST00000698732.1
ENST00000698734.1
ENST00000698731.1
Q7Z755
R4GMX2
A0A8V8TM70
O14802
ENST00000698733.1