POLK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006281Biological processDNA repair
GO_0006297Biological processnucleotide-excision repair, DNA gap filling
GO_0006260Biological processDNA replication
GO_0042276Biological processerror-prone translesion synthesis
GO_0034644Biological processcellular response to UV
GO_0090734Cellular componentsite of DNA damage
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0046872Molecular functionmetal ion binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePOLK
Protein nameDNA polymerase kappa
DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)
Alternative protein POLK
SynonymshCG_18353
DINB1
DescriptionFUNCTION: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. .

AccessionsD6RAE5
ENST00000241436.9 [Q9UBT6-1]
D6RAI7
ENST00000510815.6 [Q9UBT6-4]
ENST00000514141.5
ENST00000511527.5
L8E8A5
ENST00000505975.5
ENST00000504026.5 [Q9UBT6-6]
ENST00000514296.5
ENST00000503479.6
D6RDX9
Q9UBT6
ENST00000509126.2 [Q9UBT6-5]
ENST00000515295.5 [Q9UBT6-2]
D6R9M8
ENST00000508526.5 [Q9UBT6-3]
ENST00000505774.5