POLD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POLD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLD1 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0055089Biological processfatty acid homeostasis
GO_0034644Biological processcellular response to UV
GO_0006287Biological processbase-excision repair, gap-filling
GO_0009411Biological processresponse to UV
GO_0006260Biological processDNA replication
GO_0070987Biological processerror-free translesion synthesis
GO_0045004Biological processDNA replication proofreading
GO_0071897Biological processDNA biosynthetic process
GO_0000731Biological processDNA synthesis involved in DNA repair
GO_0006297Biological processnucleotide-excision repair, DNA gap filling
GO_0006261Biological processDNA-templated DNA replication
GO_0016020Cellular componentmembrane
GO_0016235Cellular componentaggresome
GO_0005654Cellular componentnucleoplasm
GO_0043625Cellular componentdelta DNA polymerase complex
GO_0005829Cellular componentcytosol
GO_0000109Cellular componentnucleotide-excision repair complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0003682Molecular functionchromatin binding
GO_0008296Molecular function3'-5'-DNA exonuclease activity
GO_0000166Molecular functionnucleotide binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePOLD1
Protein nameDNA-directed DNA polymerase (EC 2.7.7.7)
DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease)
DNA polymerase (EC 2.7.7.7)
DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125)
DNA polymerase delta catalytic subunit
SynonymsPOLD
DescriptionFUNCTION: As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities . Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 . Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated . Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation . Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) . Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine, 8oxoG or abasic sites . .

AccessionsENST00000643407.1
ENST00000600859.5
ENST00000599857.7
ENST00000613923.6
A0A2R8Y705
ENST00000593887
ENST00000440232.7
P28340
ENST00000644560.2
A0A2R8Y7K6
M0QXQ2
ENST00000593887.2
ENST00000593407.5
M0QZR8
ENST00000601098.6
ENST00000593981.1
M0R2J2
ENST00000687454.1
M0R2B7
A0A087WYJ2
ENST00000595904.6
M0QXE6