PNPT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0000965Biological processmitochondrial RNA 3'-end processing
GO_2000772Biological processregulation of cellular senescence
GO_0006397Biological processmRNA processing
GO_0006402Biological processmRNA catabolic process
GO_0035927Biological processRNA import into mitochondrion
GO_0043457Biological processregulation of cellular respiration
GO_0035928Biological processrRNA import into mitochondrion
GO_0070207Biological processprotein homotrimerization
GO_0000964Biological processmitochondrial RNA 5'-end processing
GO_0035458Biological processcellular response to interferon-beta
GO_0006401Biological processRNA catabolic process
GO_0060416Biological processresponse to growth hormone
GO_0051591Biological processresponse to cAMP
GO_0000962Biological processpositive regulation of mitochondrial RNA catabolic process
GO_0007005Biological processmitochondrion organization
GO_0034599Biological processcellular response to oxidative stress
GO_0071042Biological processnuclear polyadenylation-dependent mRNA catabolic process
GO_0000958Biological processmitochondrial mRNA catabolic process
GO_0097421Biological processliver regeneration
GO_0000957Biological processmitochondrial RNA catabolic process
GO_2000627Biological processpositive regulation of miRNA catabolic process
GO_0045926Biological processnegative regulation of growth
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0051726Biological processregulation of cell cycle
GO_0097222Biological processmitochondrial mRNA polyadenylation
GO_0045025Cellular componentmitochondrial degradosome
GO_0005840Cellular componentribosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0034046Molecular functionpoly(G) binding
GO_0042802Molecular functionidentical protein binding
GO_0008266Molecular functionpoly(U) RNA binding
GO_0003723Molecular functionRNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0004654Molecular functionpolyribonucleotide nucleotidyltransferase activity
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePNPT1
Protein namePolyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)
Polyribonucleotide nucleotidyltransferase 1
SynonymsPNPASE
DescriptionFUNCTION: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules . Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. .

AccessionsENST00000415374.5
ENST00000625249.1
Q8TCS8
ENST00000260604.8
H7C3C5
F8WBI3
ENST00000415489.1
ENST00000429805.1
H7BXF6
ENST00000447944.7