Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 35 studies | 34% ± 13% | |
macrophage | 18 studies | 32% ± 16% | |
pericyte | 14 studies | 25% ± 12% | |
capillary endothelial cell | 10 studies | 29% ± 11% | |
myeloid cell | 10 studies | 24% ± 6% | |
endothelial cell of lymphatic vessel | 10 studies | 25% ± 10% | |
endothelial cell of artery | 9 studies | 33% ± 15% | |
vein endothelial cell | 9 studies | 37% ± 19% | |
endothelial cell of vascular tree | 6 studies | 25% ± 11% | |
microglial cell | 5 studies | 21% ± 4% | |
classical monocyte | 4 studies | 21% ± 6% | |
glomerular endothelial cell | 3 studies | 24% ± 2% | |
monocyte | 3 studies | 23% ± 7% | |
endothelial cell of sinusoid | 3 studies | 44% ± 27% | |
fibroblast | 3 studies | 19% ± 3% |
Insufficient scRNA-seq data for expression of PLXND1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 9857.46 | 652 / 653 | 100% | 68.09 | 604 / 605 |
breast | 100% | 14744.38 | 459 / 459 | 99% | 65.67 | 1109 / 1118 |
lung | 100% | 17288.40 | 578 / 578 | 97% | 53.66 | 1117 / 1155 |
uterus | 100% | 11214.75 | 170 / 170 | 93% | 35.81 | 429 / 459 |
skin | 94% | 6421.95 | 1708 / 1809 | 97% | 63.96 | 457 / 472 |
esophagus | 93% | 5049.56 | 1350 / 1445 | 95% | 42.37 | 174 / 183 |
kidney | 100% | 6794.49 | 89 / 89 | 88% | 66.18 | 794 / 901 |
intestine | 99% | 5741.87 | 954 / 966 | 88% | 30.19 | 463 / 527 |
adrenal gland | 100% | 6657.84 | 258 / 258 | 87% | 38.03 | 199 / 230 |
bladder | 100% | 7243.57 | 21 / 21 | 86% | 29.52 | 431 / 504 |
ovary | 94% | 4394.91 | 170 / 180 | 90% | 36.18 | 387 / 430 |
stomach | 91% | 3769.09 | 325 / 359 | 90% | 37.91 | 257 / 286 |
brain | 78% | 3178.28 | 2049 / 2642 | 99% | 39.42 | 695 / 705 |
prostate | 99% | 6494.63 | 243 / 245 | 67% | 13.08 | 338 / 502 |
pancreas | 67% | 1877.32 | 220 / 328 | 98% | 44.34 | 174 / 178 |
liver | 57% | 1688.06 | 129 / 226 | 86% | 25.80 | 348 / 406 |
adipose | 100% | 18005.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 46.82 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 51.61 | 29 / 29 |
spleen | 100% | 11025.87 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 24.18 | 1 / 1 |
blood vessel | 100% | 10574.05 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 6807.63 | 854 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 32.10 | 44 / 45 |
peripheral blood | 62% | 2328.13 | 575 / 929 | 0% | 0 | 0 / 0 |
muscle | 60% | 1581.69 | 484 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001525 | Biological process | angiogenesis |
GO_0008039 | Biological process | synaptic target recognition |
GO_0035904 | Biological process | aorta development |
GO_0003151 | Biological process | outflow tract morphogenesis |
GO_0050772 | Biological process | positive regulation of axonogenesis |
GO_0007162 | Biological process | negative regulation of cell adhesion |
GO_0001822 | Biological process | kidney development |
GO_0060976 | Biological process | coronary vasculature development |
GO_0060666 | Biological process | dichotomous subdivision of terminal units involved in salivary gland branching |
GO_0045765 | Biological process | regulation of angiogenesis |
GO_0003279 | Biological process | cardiac septum development |
GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_0043542 | Biological process | endothelial cell migration |
GO_0030334 | Biological process | regulation of cell migration |
GO_0008360 | Biological process | regulation of cell shape |
GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
GO_0007416 | Biological process | synapse assembly |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0002116 | Cellular component | semaphorin receptor complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0031258 | Cellular component | lamellipodium membrane |
GO_0044297 | Cellular component | cell body |
GO_0030424 | Cellular component | axon |
GO_0030027 | Cellular component | lamellipodium |
GO_0017154 | Molecular function | semaphorin receptor activity |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PLXND1 |
Protein name | Plexin-D1 Plexin D1 PLXND1 protein |
Synonyms | KIAA0620 |
Description | FUNCTION: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. . |
Accessions | H0YAM9 ENST00000504689.1 ENST00000324093.9 [Q9Y4D7-1] Q6P657 H0YA64 Q9Y4D7 ENST00000505237.2 ENST00000506979.1 D6RH25 H0YAB2 ENST00000512744.5 H0Y9D1 ENST00000505665.5 |