PLXND1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLXND1 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0008039Biological processsynaptic target recognition
GO_0035904Biological processaorta development
GO_0003151Biological processoutflow tract morphogenesis
GO_0050772Biological processpositive regulation of axonogenesis
GO_0007162Biological processnegative regulation of cell adhesion
GO_0001822Biological processkidney development
GO_0060976Biological processcoronary vasculature development
GO_0060666Biological processdichotomous subdivision of terminal units involved in salivary gland branching
GO_0045765Biological processregulation of angiogenesis
GO_0003279Biological processcardiac septum development
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0043087Biological processregulation of GTPase activity
GO_0043542Biological processendothelial cell migration
GO_0030334Biological processregulation of cell migration
GO_0008360Biological processregulation of cell shape
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0007416Biological processsynapse assembly
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0098978Cellular componentglutamatergic synapse
GO_0002116Cellular componentsemaphorin receptor complex
GO_0005886Cellular componentplasma membrane
GO_0031258Cellular componentlamellipodium membrane
GO_0044297Cellular componentcell body
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0017154Molecular functionsemaphorin receptor activity
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLXND1
Protein namePlexin-D1
Plexin D1
PLXND1 protein
SynonymsKIAA0620
DescriptionFUNCTION: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. .

AccessionsH0YAM9
ENST00000504689.1
ENST00000324093.9 [Q9Y4D7-1]
Q6P657
H0YA64
Q9Y4D7
ENST00000505237.2
ENST00000506979.1
D6RH25
H0YAB2
ENST00000512744.5
H0Y9D1
ENST00000505665.5