PLXNA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008360Biological processregulation of cell shape
GO_0051642Biological processcentrosome localization
GO_0007162Biological processnegative regulation of cell adhesion
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0021935Biological processcerebellar granule cell precursor tangential migration
GO_0043087Biological processregulation of GTPase activity
GO_0050772Biological processpositive regulation of axonogenesis
GO_0021915Biological processneural tube development
GO_0030334Biological processregulation of cell migration
GO_0060174Biological processlimb bud formation
GO_0001756Biological processsomitogenesis
GO_0060037Biological processpharyngeal system development
GO_0002116Cellular componentsemaphorin receptor complex
GO_0005886Cellular componentplasma membrane
GO_0017154Molecular functionsemaphorin receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLXNA2
Protein namePlexin-A2 (Semaphorin receptor OCT)
SynonymsPLXN2
KIAA0463
UNQ209/PRO235
OCT
DescriptionFUNCTION: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). .

AccessionsO75051
ENST00000367033.4 [O75051-1]