PLK4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLK4 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0046601Biological processpositive regulation of centriole replication
GO_0060707Biological processtrophoblast giant cell differentiation
GO_0098535Biological processde novo centriole assembly involved in multi-ciliated epithelial cell differentiation
GO_0006468Biological processprotein phosphorylation
GO_0007099Biological processcentriole replication
GO_0005730Cellular componentnucleolus
GO_0098536Cellular componentdeuterosome
GO_0120098Cellular componentprocentriole
GO_0005813Cellular componentcentrosome
GO_0005814Cellular componentcentriole
GO_0005829Cellular componentcytosol
GO_0120099Cellular componentprocentriole replication complex
GO_0032154Cellular componentcleavage furrow
GO_0001741Cellular componentXY body
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLK4
Protein namePolo-like kinase 4
Polo like kinase 4
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (Serine/threonine-protein kinase SAK)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
SynonymsSAK
STK18
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification . Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites . .

AccessionsH0YAL6
O00444
ENST00000270861.10 [O00444-1]
J3KR84
ENST00000507249.5
ENST00000513090.5 [O00444-2]
J3KR82
A0A090BML5
ENST00000515069.5
ENST00000514379.5 [O00444-3]
ENST00000508113.1