PLA2G10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G10 at tissue level.

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0036335Biological processintestinal stem cell homeostasis
GO_0042116Biological processmacrophage activation
GO_0090370Biological processnegative regulation of cholesterol efflux
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0043249Biological processerythrocyte maturation
GO_2000344Biological processpositive regulation of acrosome reaction
GO_0006658Biological processphosphatidylserine metabolic process
GO_0051607Biological processdefense response to virus
GO_0031069Biological processhair follicle morphogenesis
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0043030Biological processregulation of macrophage activation
GO_0090238Biological processpositive regulation of arachidonic acid secretion
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0002532Biological processproduction of molecular mediator involved in inflammatory response
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0009566Biological processfertilization
GO_0050728Biological processnegative regulation of inflammatory response
GO_0001516Biological processprostaglandin biosynthetic process
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0046473Biological processphosphatidic acid metabolic process
GO_0062234Biological processplatelet activating factor catabolic process
GO_0032308Biological processpositive regulation of prostaglandin secretion
GO_0006644Biological processphospholipid metabolic process
GO_0046337Biological processphosphatidylethanolamine metabolic process
GO_0010884Biological processpositive regulation of lipid storage
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0051977Biological processlysophospholipid transport
GO_0007411Biological processaxon guidance
GO_0042632Biological processcholesterol homeostasis
GO_0050482Biological processarachidonic acid secretion
GO_0005615Cellular componentextracellular space
GO_0001669Cellular componentacrosomal vesicle
GO_0005576Cellular componentextracellular region
GO_0005764Cellular componentlysosome
GO_0004620Molecular functionphospholipase activity
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005543Molecular functionphospholipid binding
GO_0004623Molecular functionphospholipase A2 activity
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLA2G10
Protein namePhospholipase A2 (EC 3.1.1.4)
Alternative protein PLA2G10
Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10)
SynonymshCG_1746186
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids . Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls . Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles . Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells . Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL . May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response (By similarity). Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen (By similarity). Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration (By similarity). May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis (By similarity). By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility (By similarity). May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria . Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane . In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells . May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity). .

AccessionsENST00000567462.1
ENST00000621727.2
L8E7V2
H3BRW4
ENST00000634009.1
O15496
ENST00000438167.8