I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 4 studies | 25% ± 4% | |
| CD8-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
| natural killer cell | 3 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 4 studies | 25% ± 4% | |
| CD8-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
| natural killer cell | 3 studies | 25% ± 4% |
Insufficient scRNA-seq data for expression of PKMYT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 92% | 598.38 | 1667 / 1809 | 95% | 17.57 | 450 / 472 |
| lung | 80% | 173.76 | 465 / 578 | 85% | 11.32 | 977 / 1155 |
| stomach | 59% | 167.94 | 212 / 359 | 95% | 18.24 | 272 / 286 |
| intestine | 54% | 209.95 | 524 / 966 | 95% | 20.35 | 502 / 527 |
| esophagus | 45% | 318.99 | 655 / 1445 | 100% | 22.36 | 183 / 183 |
| brain | 80% | 134.54 | 2111 / 2642 | 60% | 5.62 | 422 / 705 |
| bladder | 29% | 28.24 | 6 / 21 | 93% | 15.90 | 467 / 504 |
| breast | 32% | 40.30 | 149 / 459 | 87% | 12.16 | 976 / 1118 |
| uterus | 11% | 21.29 | 19 / 170 | 98% | 24.35 | 450 / 459 |
| pancreas | 38% | 35.73 | 126 / 328 | 71% | 5.24 | 126 / 178 |
| ovary | 9% | 15.52 | 17 / 180 | 97% | 13.18 | 417 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 25.12 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 29.68 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.18 | 1 / 1 |
| spleen | 100% | 451.49 | 240 / 241 | 0% | 0 | 0 / 0 |
| prostate | 67% | 88.81 | 164 / 245 | 23% | 1.41 | 114 / 502 |
| peripheral blood | 89% | 657.53 | 823 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 61% | 72.84 | 157 / 258 | 23% | 2.94 | 54 / 230 |
| liver | 34% | 57.73 | 77 / 226 | 41% | 2.94 | 167 / 406 |
| eye | 0% | 0 | 0 / 0 | 53% | 2.62 | 42 / 80 |
| kidney | 30% | 66.78 | 27 / 89 | 10% | 0.62 | 91 / 901 |
| thymus | 23% | 24.56 | 152 / 653 | 17% | 3.53 | 101 / 605 |
| adipose | 35% | 48.79 | 424 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 17% | 18.26 | 221 / 1335 | 0% | 0 | 0 / 0 |
| heart | 14% | 15.48 | 119 / 861 | 0% | 0 | 0 / 0 |
| muscle | 2% | 1.77 | 18 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0000079 | Biological process | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO_0110031 | Biological process | negative regulation of G2/MI transition of meiotic cell cycle |
| GO_0051321 | Biological process | meiotic cell cycle |
| GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0010972 | Biological process | negative regulation of G2/M transition of mitotic cell cycle |
| GO_0007088 | Biological process | regulation of mitotic nuclear division |
| GO_0005730 | Cellular component | nucleolus |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0016301 | Molecular function | kinase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PKMYT1 |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Protein kinase, membrane associated tyrosine/threonine 1 |
| Synonyms | MYT1 |
| Description | FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins . Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation . May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect . . |
| Accessions | B4DZM6 ENST00000573944.5 [Q99640-3] ENST00000575040.1 I3L4K3 ENST00000574730.5 [Q99640-4] A6NHV6 I3L4Y0 ENST00000572059.1 ENST00000576268.1 I3L1H7 I3L136 ENST00000574415.5 ENST00000382240.9 Q99640 ENST00000572619.1 Q0IJ49 I3L3P0 ENST00000262300.13 [Q99640-1] ENST00000575632.5 ENST00000431515.6 ENST00000440027.6 [Q99640-2] ENST00000574385.5 [Q99640-3] I3L2S4 |
