PKD2L1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PKD2L1 at tissue level.

III. Associated gene sets

GO_0007224Biological processsmoothened signaling pathway
GO_0050982Biological processdetection of mechanical stimulus
GO_0009415Biological processresponse to water
GO_0098662Biological processinorganic cation transmembrane transport
GO_0001581Biological processdetection of chemical stimulus involved in sensory perception of sour taste
GO_0071468Biological processcellular response to acidic pH
GO_0050915Biological processsensory perception of sour taste
GO_0071805Biological processpotassium ion transmembrane transport
GO_0006812Biological processmonoatomic cation transport
GO_0050912Biological processdetection of chemical stimulus involved in sensory perception of taste
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0051289Biological processprotein homotetramerization
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0060170Cellular componentciliary membrane
GO_0009986Cellular componentcell surface
GO_0015629Cellular componentactin cytoskeleton
GO_0097730Cellular componentnon-motile cilium
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0034704Cellular componentcalcium channel complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005272Molecular functionsodium channel activity
GO_0033040Molecular functionsour taste receptor activity
GO_0015269Molecular functioncalcium-activated potassium channel activity
GO_0051371Molecular functionmuscle alpha-actinin binding
GO_0042802Molecular functionidentical protein binding
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0008324Molecular functionmonoatomic cation transmembrane transporter activity
GO_0051393Molecular functionalpha-actinin binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005509Molecular functioncalcium ion binding
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity
GO_0005227Molecular functioncalcium-activated cation channel activity

IV. Literature review

[source]
Gene namePKD2L1
Protein namePolycystic kidney disease 2-like 1 variant
Polycystin 2 like 1, transient receptor potential cation channel
Polycystin-2-like protein 1 (Polycystin-2L1) (Polycystic kidney disease 2-like 1 protein) (Polycystin-2 homolog) (Polycystin-L) (Polycystin-L1)
SynonymsPKDL
PKD2L
TRPP3
DescriptionFUNCTION: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) . Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration . The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription . Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells . The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again . May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity). .

AccessionsE9PRD1
Q9P0L9
ENST00000465680.2
H0YET4
ENST00000532547.1
ENST00000318222.4 [Q9P0L9-1]
Q1L4F0
ENST00000528248.1
H0YDN7