I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 4 studies | 73% ± 18% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 4 studies | 73% ± 18% |
Insufficient scRNA-seq data for expression of PITX2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3304.90 | 21 / 21 | 74% | 4.81 | 373 / 504 |
| esophagus | 78% | 764.14 | 1133 / 1445 | 62% | 5.38 | 114 / 183 |
| intestine | 26% | 200.54 | 253 / 966 | 79% | 6.45 | 415 / 527 |
| muscle | 100% | 3185.48 | 803 / 803 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.73 | 1 / 1 |
| skin | 42% | 226.21 | 768 / 1809 | 46% | 2.27 | 216 / 472 |
| stomach | 14% | 56.70 | 49 / 359 | 53% | 4.24 | 152 / 286 |
| uterus | 2% | 8.88 | 4 / 170 | 62% | 7.16 | 286 / 459 |
| eye | 0% | 0 | 0 / 0 | 64% | 3.07 | 51 / 80 |
| lung | 0% | 0 | 0 / 578 | 50% | 3.71 | 574 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 5.29 | 19 / 45 |
| prostate | 22% | 103.81 | 54 / 245 | 11% | 0.25 | 56 / 502 |
| breast | 9% | 19.17 | 43 / 459 | 18% | 0.47 | 202 / 1118 |
| kidney | 2% | 6.07 | 2 / 89 | 21% | 1.52 | 191 / 901 |
| ovary | 0% | 0 | 0 / 180 | 18% | 0.65 | 77 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 16% | 0.82 | 28 / 178 |
| brain | 3% | 27.72 | 87 / 2642 | 7% | 0.59 | 51 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.07 | 2 / 29 |
| liver | 0% | 0 | 0 / 226 | 6% | 0.30 | 23 / 406 |
| heart | 4% | 39.07 | 37 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 1.11 | 1 / 258 | 3% | 0.09 | 7 / 230 |
| thymus | 1% | 1.84 | 4 / 653 | 1% | 0.04 | 8 / 605 |
| adipose | 1% | 2.75 | 15 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 1.93 | 6 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.70 | 6 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0070986 | Biological process | left/right axis specification |
| GO_0042476 | Biological process | odontogenesis |
| GO_0007368 | Biological process | determination of left/right symmetry |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0035315 | Biological process | hair cell differentiation |
| GO_0060971 | Biological process | embryonic heart tube left/right pattern formation |
| GO_0048536 | Biological process | spleen development |
| GO_0035993 | Biological process | deltoid tuberosity development |
| GO_0009653 | Biological process | anatomical structure morphogenesis |
| GO_0060126 | Biological process | somatotropin secreting cell differentiation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0061072 | Biological process | iris morphogenesis |
| GO_0043010 | Biological process | camera-type eye development |
| GO_0060127 | Biological process | prolactin secreting cell differentiation |
| GO_0003253 | Biological process | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PITX2 |
| Protein name | Homeobox protein Paired like homeodomain 2 Pituitary homeobox 2 (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) |
| Synonyms | RGS RIEG1 ARP1 RIEG |
| Description | FUNCTION: May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. .; FUNCTION: [Isoform PTX2C]: Involved in the establishment of left-right asymmetry in the developing embryo. . |
| Accessions | ENST00000644743.1 [Q99697-2] ENST00000511837.5 A0A8J9C2I7 ENST00000354925.6 [Q99697-1] U3KQ81 ENST00000557119.2 A0A8J9G9V2 ENST00000355080.9 [Q99697-3] ENST00000614423.5 ENST00000394595.8 [Q99697-1] D6RBG8 D6RFI4 Q99697 ENST00000511990.1 ENST00000613094.5 |
