PIP5K1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0012505Cellular componentendomembrane system
GO_0005829Cellular componentcytosol
GO_0001931Cellular componenturopod
GO_0005886Cellular componentplasma membrane
GO_0052742Molecular functionphosphatidylinositol kinase activity
GO_0000285Molecular function1-phosphatidylinositol-3-phosphate 5-kinase activity
GO_0005515Molecular functionprotein binding
GO_0016308Molecular function1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0052810Molecular function1-phosphatidylinositol-5-kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePIP5K1B
Protein namePhosphatidylinositol-4-phosphate 5-kinase type 1 beta
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)
SynonymsSTM7
DescriptionFUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). .

AccessionsA0A0A0MT25
ENST00000440050.5
ENST00000377284.5
A0A0A0MRU3
ENST00000265382.8 [O14986-1]
ENST00000437200.5
A0A0A0MSP5
ENST00000478500.3 [O14986-2]
O14986
ENST00000541509.5 [O14986-3]