PIEZO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006812Biological processmonoatomic cation transport
GO_0050982Biological processdetection of mechanical stimulus
GO_0033634Biological processpositive regulation of cell-cell adhesion mediated by integrin
GO_0042391Biological processregulation of membrane potential
GO_0071260Biological processcellular response to mechanical stimulus
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0010831Biological processpositive regulation of myotube differentiation
GO_0033625Biological processpositive regulation of integrin activation
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0031258Cellular componentlamellipodium membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0140135Molecular functionmechanosensitive monoatomic cation channel activity
GO_0008381Molecular functionmechanosensitive monoatomic ion channel activity
GO_0005515Molecular functionprotein binding
GO_0005261Molecular functionmonoatomic cation channel activity

IV. Literature review

[source]
Gene namePIEZO1
Protein namePiezo type mechanosensitive ion channel component 1
PIEZO1
Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)
SynonymsKIAA0233
FAM38A
DescriptionFUNCTION: Pore-forming subunit of a mechanosensitive non-specific cation channel . Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents . Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling . In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation . Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation . .

AccessionsENST00000419505.5
M4QHP2
ENST00000327397.8
Q92508
H7C2J5
H0YB49
ENST00000466823.3
H3BRR7
H3BSF6
ENST00000474606.1
E7EUT2
ENST00000518793.6
ENST00000301015.14