Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 21% ± 3% | |
endothelial cell of lymphatic vessel | 13 studies | 30% ± 9% | |
adipocyte | 8 studies | 25% ± 7% | |
capillary endothelial cell | 6 studies | 19% ± 1% | |
microglial cell | 5 studies | 19% ± 4% | |
type I pneumocyte | 5 studies | 22% ± 5% | |
non-classical monocyte | 4 studies | 26% ± 10% | |
classical monocyte | 3 studies | 24% ± 4% | |
glomerular endothelial cell | 3 studies | 20% ± 2% | |
epithelial cell | 3 studies | 19% ± 1% | |
endothelial cell of vascular tree | 3 studies | 21% ± 3% | |
lymphocyte | 3 studies | 19% ± 3% | |
astrocyte | 3 studies | 24% ± 3% | |
dendritic cell | 3 studies | 22% ± 6% | |
vein endothelial cell | 3 studies | 21% ± 6% | |
macrophage | 3 studies | 18% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
liver | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 11333.34 | 1445 / 1445 | 100% | 58.84 | 183 / 183 |
prostate | 100% | 11339.90 | 245 / 245 | 100% | 60.19 | 500 / 502 |
intestine | 100% | 14454.62 | 966 / 966 | 99% | 47.14 | 522 / 527 |
thymus | 100% | 8340.59 | 652 / 653 | 99% | 23.40 | 598 / 605 |
breast | 100% | 14297.40 | 459 / 459 | 99% | 36.61 | 1102 / 1118 |
skin | 100% | 11898.78 | 1809 / 1809 | 98% | 35.77 | 463 / 472 |
lung | 100% | 15414.30 | 578 / 578 | 97% | 34.08 | 1124 / 1155 |
uterus | 100% | 10516.84 | 170 / 170 | 97% | 36.66 | 443 / 459 |
bladder | 100% | 13266.00 | 21 / 21 | 96% | 40.24 | 485 / 504 |
stomach | 96% | 6601.03 | 345 / 359 | 98% | 43.38 | 281 / 286 |
kidney | 100% | 8351.88 | 89 / 89 | 88% | 25.05 | 795 / 901 |
liver | 99% | 4212.98 | 224 / 226 | 87% | 18.81 | 354 / 406 |
pancreas | 69% | 2126.94 | 227 / 328 | 96% | 42.13 | 171 / 178 |
brain | 70% | 2037.42 | 1838 / 2642 | 92% | 17.51 | 646 / 705 |
ovary | 91% | 3592.85 | 163 / 180 | 70% | 13.74 | 303 / 430 |
adrenal gland | 100% | 4606.05 | 257 / 258 | 45% | 7.80 | 104 / 230 |
adipose | 100% | 14643.41 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 12811.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.85 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 57.05 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 29.42 | 79 / 80 |
blood vessel | 96% | 5145.23 | 1283 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 16.81 | 26 / 29 |
heart | 86% | 2872.98 | 741 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 73% | 4581.28 | 681 / 929 | 0% | 0 | 0 / 0 |
muscle | 12% | 270.94 | 93 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006812 | Biological process | monoatomic cation transport |
GO_0050982 | Biological process | detection of mechanical stimulus |
GO_0033634 | Biological process | positive regulation of cell-cell adhesion mediated by integrin |
GO_0042391 | Biological process | regulation of membrane potential |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0098655 | Biological process | monoatomic cation transmembrane transport |
GO_0010831 | Biological process | positive regulation of myotube differentiation |
GO_0033625 | Biological process | positive regulation of integrin activation |
GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
GO_0031258 | Cellular component | lamellipodium membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0140135 | Molecular function | mechanosensitive monoatomic cation channel activity |
GO_0008381 | Molecular function | mechanosensitive monoatomic ion channel activity |
GO_0005515 | Molecular function | protein binding |
GO_0005261 | Molecular function | monoatomic cation channel activity |
Gene name | PIEZO1 |
Protein name | Piezo type mechanosensitive ion channel component 1 PIEZO1 Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) |
Synonyms | KIAA0233 FAM38A |
Description | FUNCTION: Pore-forming subunit of a mechanosensitive non-specific cation channel . Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents . Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling . In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation . Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation . . |
Accessions | ENST00000419505.5 M4QHP2 ENST00000327397.8 Q92508 H7C2J5 H0YB49 ENST00000466823.3 H3BRR7 H3BSF6 ENST00000474606.1 E7EUT2 ENST00000518793.6 ENST00000301015.14 |