PHF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061188Biological processnegative regulation of rDNA heterochromatin formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006482Biological processprotein demethylation
GO_0001889Biological processliver development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0005730Cellular componentnucleolus
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0032452Molecular functionhistone demethylase activity
GO_0005506Molecular functioniron ion binding
GO_0008270Molecular functionzinc ion binding
GO_0035575Molecular functionhistone H4K20 demethylase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePHF2
Protein namePHD finger protein 2
PHF2 protein
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
SynonymsCENP-35
KIAA0662
GRC5
DescriptionFUNCTION: Lysine demethylase that demethylates both histones and non-histone proteins . Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B . Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes . The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA . Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity). .

AccessionsQ8N359
Q6P2C5
ENST00000375376.8
A0A087WW48
ENST00000359246.9
ENST00000610682.1
O75151
E7ET14