PHEX | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	6 studies	24% ± 10%	Explore
astrocyte	3 studies	27% ± 13%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PHEX at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	154.20	2577 / 2642	76%	2.93	536 / 705
thymus	98%	362.39	641 / 653	72%	25.93	435 / 605
breast	87%	153.21	399 / 459	73%	2.94	811 / 1118
lung	100%	875.30	577 / 578	50%	1.47	579 / 1155
uterus	95%	467.29	161 / 170	42%	2.92	191 / 459
esophagus	81%	129.88	1164 / 1445	37%	1.00	68 / 183
ovary	91%	327.64	164 / 180	14%	0.37	59 / 430
prostate	93%	122.68	229 / 245	9%	0.14	47 / 502
skin	67%	40.29	1204 / 1809	34%	1.05	162 / 472
spleen	87%	76.72	209 / 241	0%	0	0 / 0
intestine	77%	74.95	748 / 966	6%	0.12	31 / 527
kidney	49%	23.79	44 / 89	27%	0.74	246 / 901
bladder	43%	18.48	9 / 21	24%	0.82	120 / 504
blood vessel	52%	32.64	695 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	2.15	10 / 29
adrenal gland	30%	17.81	77 / 258	3%	0.09	7 / 230
tonsil	0%	0	0 / 0	24%	0.43	11 / 45
stomach	15%	6.12	55 / 359	7%	0.12	21 / 286
adipose	22%	9.41	260 / 1204	0%	0	0 / 0
peripheral blood	19%	25.12	174 / 929	0%	0	0 / 0
pancreas	9%	3.05	28 / 328	8%	0.14	15 / 178
liver	1%	0.42	3 / 226	11%	0.33	46 / 406
heart	9%	3.56	75 / 861	0%	0	0 / 0
muscle	4%	3.43	35 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1990418	Biological process	response to insulin-like growth factor stimulus
GO_0030324	Biological process	lung development
GO_0042476	Biological process	odontogenesis
GO_0071305	Biological process	cellular response to vitamin D
GO_0016485	Biological process	protein processing
GO_0071374	Biological process	cellular response to parathyroid hormone stimulus
GO_1904383	Biological process	response to sodium phosphate
GO_0007267	Biological process	cell-cell signaling
GO_0060416	Biological process	response to growth hormone
GO_0036211	Biological process	protein modification process
GO_0006508	Biological process	proteolysis
GO_0030282	Biological process	bone mineralization
GO_0001501	Biological process	skeletal system development
GO_0019637	Biological process	organophosphate metabolic process
GO_0060348	Biological process	bone development
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0008270	Molecular function	zinc ion binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding

Gene name	PHEX
Protein name	Phosphate regulating endopeptidase X-linked Phosphate-regulating neutral endopeptidase PHEX (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)
Synonyms	PEX
Description	FUNCTION: Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity . Cleaves ASARM peptides between Ser and Glu or Asp residues . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides . Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation . .
Accessions	ENST00000684356.1 A0A804HKT0 ENST00000684143.1 P78562 ENST00000683289.1 A0A804HKN7 A0A804HL45 A0A804HJR7 A0A804HLA0 ENST00000682888.1 ENST00000683162.1 ENST00000379374.5

PHEX report