PGRMC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060612Biological processadipose tissue development
GO_0015886Biological processheme transport
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0005635Cellular componentnuclear envelope
GO_0012505Cellular componentendomembrane system
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0005496Molecular functionsteroid binding
GO_0003707Molecular functionnuclear steroid receptor activity

IV. Literature review

[source]
Gene namePGRMC2
Protein nameProgesterone receptor membrane component 2
Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)
SynonymsDG6
hCG_16401
PMBP
DescriptionFUNCTION: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis . In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). .

AccessionsENST00000509070.1
U3KQM0
U3KPU8
ENST00000520121.6 [O15173-1]
O15173
ENST00000503872.1
ENST00000296425.10 [O15173-1]
U3KQ70
ENST00000503588.1
ENST00000512483.5
ENST00000613358.4 [O15173-2]
ENST00000394276.3