Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 8 studies | 18% ± 3% | |
ciliated cell | 6 studies | 26% ± 9% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 17% ± 2% | |
fibroblast | 5 studies | 20% ± 5% | |
epithelial cell | 5 studies | 35% ± 15% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 20% ± 3% | |
endothelial cell | 4 studies | 23% ± 6% | |
astrocyte | 4 studies | 26% ± 5% | |
oligodendrocyte precursor cell | 4 studies | 22% ± 6% | |
non-classical monocyte | 3 studies | 22% ± 7% | |
GABAergic neuron | 3 studies | 21% ± 5% | |
glutamatergic neuron | 3 studies | 24% ± 6% | |
goblet cell | 3 studies | 19% ± 4% | |
intestinal crypt stem cell | 3 studies | 18% ± 3% | |
oligodendrocyte | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1669.51 | 1445 / 1445 | 100% | 22.68 | 183 / 183 |
ovary | 100% | 1721.96 | 180 / 180 | 100% | 32.43 | 430 / 430 |
prostate | 100% | 2341.29 | 245 / 245 | 100% | 39.42 | 502 / 502 |
uterus | 100% | 2209.35 | 170 / 170 | 100% | 28.66 | 459 / 459 |
brain | 100% | 1575.31 | 2641 / 2642 | 100% | 35.69 | 705 / 705 |
breast | 100% | 2028.47 | 459 / 459 | 100% | 44.21 | 1117 / 1118 |
lung | 100% | 1750.18 | 577 / 578 | 100% | 33.95 | 1155 / 1155 |
bladder | 100% | 1908.10 | 21 / 21 | 100% | 29.40 | 503 / 504 |
thymus | 100% | 2188.10 | 653 / 653 | 100% | 33.75 | 603 / 605 |
stomach | 100% | 1708.52 | 359 / 359 | 100% | 28.80 | 285 / 286 |
pancreas | 100% | 1331.94 | 328 / 328 | 99% | 26.00 | 177 / 178 |
intestine | 100% | 2194.07 | 966 / 966 | 99% | 30.11 | 524 / 527 |
kidney | 100% | 2060.72 | 89 / 89 | 99% | 24.60 | 895 / 901 |
liver | 100% | 1293.96 | 226 / 226 | 99% | 21.54 | 403 / 406 |
adrenal gland | 100% | 2402.69 | 258 / 258 | 98% | 22.23 | 225 / 230 |
skin | 100% | 1736.90 | 1808 / 1809 | 95% | 24.35 | 449 / 472 |
adipose | 100% | 1787.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 26.91 | 29 / 29 |
muscle | 100% | 1990.70 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2060.33 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 27.03 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 17.01 | 1 / 1 |
blood vessel | 100% | 1650.16 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1354.18 | 847 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 27.16 | 76 / 80 |
peripheral blood | 86% | 1530.03 | 795 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016558 | Biological process | protein import into peroxisome matrix |
GO_0000425 | Biological process | pexophagy |
GO_0034614 | Biological process | cellular response to reactive oxygen species |
GO_0048147 | Biological process | negative regulation of fibroblast proliferation |
GO_0044721 | Biological process | protein import into peroxisome matrix, substrate release |
GO_0016562 | Biological process | protein import into peroxisome matrix, receptor recycling |
GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
GO_0031648 | Biological process | protein destabilization |
GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
GO_0007031 | Biological process | peroxisome organization |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0006513 | Biological process | protein monoubiquitination |
GO_1990928 | Biological process | response to amino acid starvation |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0016593 | Cellular component | Cdc73/Paf1 complex |
GO_0005829 | Cellular component | cytosol |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0008320 | Molecular function | protein transmembrane transporter activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PEX2 |
Protein name | Peroxisome biogenesis factor 2 (EC 2.3.2.27) (EC 2.3.2.36) (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72) RING-type E3 ubiquitin transferase (cysteine targeting) (EC 2.3.2.36) (Peroxin-2) |
Synonyms | PMP3 PAF1 PMP35 RNF72 PXMP3 |
Description | FUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling . The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 . Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis . . |
Accessions | E5RIW9 ENST00000518986.5 ENST00000522527.5 ENST00000520103.5 ENST00000357039.9 P28328 |