PEX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0000425Biological processpexophagy
GO_0034614Biological processcellular response to reactive oxygen species
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0044721Biological processprotein import into peroxisome matrix, substrate release
GO_0016562Biological processprotein import into peroxisome matrix, receptor recycling
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0031648Biological processprotein destabilization
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0007031Biological processperoxisome organization
GO_0006635Biological processfatty acid beta-oxidation
GO_0006513Biological processprotein monoubiquitination
GO_1990928Biological processresponse to amino acid starvation
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0016593Cellular componentCdc73/Paf1 complex
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX2
Protein namePeroxisome biogenesis factor 2 (EC 2.3.2.27) (EC 2.3.2.36) (35 kDa peroxisomal membrane protein) (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) (RING finger protein 72)
RING-type E3 ubiquitin transferase (cysteine targeting) (EC 2.3.2.36) (Peroxin-2)
SynonymsPMP3
PAF1
PMP35
RNF72
PXMP3
DescriptionFUNCTION: E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling . The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (By similarity). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70 . Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis . .

AccessionsE5RIW9
ENST00000518986.5
ENST00000522527.5
ENST00000520103.5
ENST00000357039.9
P28328