PEPD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	24 studies	26% ± 10%	Explore
endothelial cell of lymphatic vessel	19 studies	37% ± 14%	Explore
classical monocyte	13 studies	27% ± 11%	Explore
endothelial cell	12 studies	26% ± 9%	Explore
non-classical monocyte	9 studies	26% ± 9%	Explore
epithelial cell of proximal tubule	8 studies	47% ± 18%	Explore
myeloid cell	7 studies	23% ± 8%	Explore
epithelial cell	7 studies	31% ± 16%	Explore
natural killer cell	6 studies	21% ± 5%	Explore
enterocyte	6 studies	45% ± 12%	Explore
fibroblast	6 studies	24% ± 11%	Explore
alveolar macrophage	6 studies	21% ± 4%	Explore
endothelial cell of artery	6 studies	20% ± 4%	Explore
mast cell	6 studies	35% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	19% ± 4%	Explore
conventional dendritic cell	5 studies	35% ± 11%	Explore
oligodendrocyte precursor cell	5 studies	24% ± 6%	Explore
smooth muscle cell	4 studies	19% ± 3%	Explore
pericyte	4 studies	20% ± 2%	Explore
astrocyte	4 studies	29% ± 9%	Explore
hepatocyte	4 studies	42% ± 21%	Explore
glutamatergic neuron	4 studies	39% ± 15%	Explore
dendritic cell	4 studies	36% ± 14%	Explore
oligodendrocyte	4 studies	27% ± 7%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
mature NK T cell	3 studies	19% ± 4%	Explore
CD8-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
capillary endothelial cell	3 studies	20% ± 1%	Explore
monocyte	3 studies	23% ± 8%	Explore
mononuclear phagocyte	3 studies	25% ± 9%	Explore
ciliated cell	3 studies	18% ± 2%	Explore
Mueller cell	3 studies	17% ± 2%	Explore
endothelial cell of vascular tree	3 studies	19% ± 2%	Explore
intermediate monocyte	3 studies	32% ± 12%	Explore
GABAergic neuron	3 studies	36% ± 6%	Explore
abnormal cell	3 studies	23% ± 4%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
interneuron	3 studies	31% ± 12%	Explore
neuron	3 studies	30% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	20% ± 4%	Explore
lung	6 studies	19% ± 1%	Explore
brain	6 studies	29% ± 9%	Explore
kidney	5 studies	27% ± 16%	Explore
liver	5 studies	21% ± 4%	Explore
intestine	3 studies	27% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3751.57	1445 / 1445	100%	43.50	183 / 183
skin	100%	3745.56	1809 / 1809	100%	95.84	472 / 472
thymus	100%	3818.40	653 / 653	100%	53.88	604 / 605
brain	100%	2701.32	2637 / 2642	100%	78.63	705 / 705
kidney	100%	14682.03	89 / 89	100%	77.64	899 / 901
ovary	100%	3197.77	180 / 180	100%	61.33	429 / 430
liver	100%	7182.60	226 / 226	100%	96.83	405 / 406
stomach	100%	2582.95	359 / 359	100%	54.81	285 / 286
lung	100%	3758.89	578 / 578	99%	52.03	1146 / 1155
uterus	100%	3715.65	170 / 170	99%	55.42	455 / 459
intestine	100%	5569.91	966 / 966	99%	53.94	522 / 527
bladder	100%	3745.24	21 / 21	99%	58.56	499 / 504
adrenal gland	100%	5189.66	258 / 258	99%	77.02	227 / 230
prostate	100%	2469.29	244 / 245	99%	44.96	495 / 502
breast	100%	4308.54	459 / 459	98%	44.89	1095 / 1118
pancreas	95%	1311.34	311 / 328	99%	47.84	176 / 178
adipose	100%	4874.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3766.06	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	118.33	80 / 80
lymph node	0%	0	0 / 0	100%	53.96	29 / 29
spleen	100%	3663.41	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	49.47	45 / 45
ureter	0%	0	0 / 0	100%	28.76	1 / 1
muscle	99%	1867.39	798 / 803	0%	0	0 / 0
heart	96%	1537.54	824 / 861	0%	0	0 / 0
peripheral blood	92%	1590.07	853 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030574	Biological process	collagen catabolic process
GO_0006508	Biological process	proteolysis
GO_0043069	Biological process	negative regulation of programmed cell death
GO_0006520	Biological process	amino acid metabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0030145	Molecular function	manganese ion binding
GO_0008233	Molecular function	peptidase activity
GO_0102009	Molecular function	proline dipeptidase activity
GO_0005515	Molecular function	protein binding
GO_0070006	Molecular function	metalloaminopeptidase activity
GO_0004181	Molecular function	metallocarboxypeptidase activity

IV. Literature review

[source]

Gene name	PEPD
Protein name	Peptidase D Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) Xaa-Pro dipeptidase (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase)
Synonyms	PRD
Description	FUNCTION: Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position . The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved . Plays an important role in collagen metabolism because the high level of iminoacids in collagen . .
Accessions	A0A8V8TN48 ENST00000590755.6 ENST00000698361.1 ENST00000651646.2 A0A8V8TN70 A0A8V8TNH5 ENST00000698430.1 A0A8V8TM81 A0A8V8TNF2 A0A8V8TLR1 A0A8V8TM86 ENST00000588328.7 ENST00000244137.12 [P12955-1] ENST00000590408.1 A0A8V8TLP4 ENST00000698360.1 ENST00000698428.1 ENST00000698426.1 P12955 K7ES25 ENST00000436370.7 [P12955-3] V9GYL0 ENST00000698431.1 ENST00000698362.1 ENST00000698359.1 ENST00000698427.1 A0A8V8TLL9 A0A494C165 V9GYE4 ENST00000698436.1 ENST00000698439.1 J3K000 A0A8V8TLR6 A0A494C194 ENST00000698432.1 ENST00000698435.1 A0A8V8TLN7 ENST00000651901.2 A0A8V8TLP2 ENST00000397032.8 [P12955-2]

PEPD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review