PELO report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PELO at tissue level.

III. Associated gene sets

GO_0060231Biological processmesenchymal to epithelial transition
GO_0070651Biological processnonfunctional rRNA decay
GO_0001833Biological processinner cell mass cell proliferation
GO_0051301Biological processcell division
GO_0072344Biological processrescue of stalled ribosome
GO_0032790Biological processribosome disassembly
GO_0006417Biological processregulation of translation
GO_0007492Biological processendoderm development
GO_0051276Biological processchromosome organization
GO_0019827Biological processstem cell population maintenance
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0071025Biological processRNA surveillance
GO_0070966Biological processnuclear-transcribed mRNA catabolic process, no-go decay
GO_0070481Biological processnuclear-transcribed mRNA catabolic process, non-stop decay
GO_0022626Cellular componentcytosolic ribosome
GO_1990533Cellular componentDom34-Hbs1 complex
GO_0005737Cellular componentcytoplasm
GO_0043022Molecular functionribosome binding
GO_0170011Molecular functionstalled ribosome sensor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePELO
Protein nameProtein pelota homolog (hPelota) (Protein Dom34 homolog)
SynonymsCGI-17
DescriptionFUNCTION: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway . In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel . Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway . As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy . .

AccessionsENST00000274311.3
Q9BRX2