I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 10 studies | 20% ± 4% | |
| endothelial cell | 6 studies | 23% ± 4% | |
| endothelial cell of lymphatic vessel | 5 studies | 21% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 10 studies | 20% ± 4% | |
| endothelial cell | 6 studies | 23% ± 4% | |
| endothelial cell of lymphatic vessel | 5 studies | 21% ± 6% |
Insufficient scRNA-seq data for expression of PEAR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4227.23 | 652 / 653 | 81% | 5.67 | 492 / 605 |
| breast | 100% | 5892.86 | 459 / 459 | 80% | 4.84 | 890 / 1118 |
| esophagus | 87% | 1888.32 | 1261 / 1445 | 90% | 6.13 | 165 / 183 |
| kidney | 99% | 2454.51 | 88 / 89 | 77% | 13.14 | 694 / 901 |
| lung | 100% | 5320.47 | 578 / 578 | 75% | 4.01 | 869 / 1155 |
| adrenal gland | 97% | 2000.83 | 250 / 258 | 78% | 8.12 | 179 / 230 |
| pancreas | 77% | 879.74 | 253 / 328 | 95% | 8.66 | 169 / 178 |
| prostate | 97% | 2216.40 | 237 / 245 | 71% | 3.17 | 357 / 502 |
| bladder | 100% | 2440.86 | 21 / 21 | 66% | 2.88 | 331 / 504 |
| intestine | 96% | 1804.20 | 923 / 966 | 69% | 3.52 | 364 / 527 |
| uterus | 100% | 4676.42 | 170 / 170 | 56% | 3.71 | 258 / 459 |
| stomach | 78% | 1230.92 | 281 / 359 | 74% | 4.42 | 212 / 286 |
| ovary | 100% | 3904.52 | 180 / 180 | 35% | 1.66 | 151 / 430 |
| skin | 87% | 2272.26 | 1574 / 1809 | 46% | 3.12 | 218 / 472 |
| brain | 27% | 268.34 | 719 / 2642 | 90% | 4.79 | 635 / 705 |
| adipose | 100% | 6944.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3949.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5079.55 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2498.98 | 853 / 861 | 0% | 0 | 0 / 0 |
| liver | 39% | 417.87 | 88 / 226 | 50% | 2.32 | 202 / 406 |
| muscle | 83% | 1033.35 | 670 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 1.69 | 22 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 1.67 | 14 / 29 |
| eye | 0% | 0 | 0 / 0 | 23% | 0.75 | 18 / 80 |
| peripheral blood | 2% | 17.90 | 17 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0070527 | Biological process | platelet aggregation |
| GO_0010572 | Biological process | positive regulation of platelet activation |
| GO_0043654 | Biological process | recognition of apoptotic cell |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0001891 | Cellular component | phagocytic cup |
| GO_0016020 | Cellular component | membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PEAR1 |
| Protein name | Platelet endothelial aggregation receptor 1 Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) |
| Synonyms | MEGF12 |
| Description | FUNCTION: Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling . May be involved in the early stages of hematopoiesis (By similarity). . |
| Accessions | ENST00000338302.7 ENST00000444016.5 Q5VY43 ENST00000455314.5 A6PVP2 ENST00000292357.8 F2Z2F7 |
