Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasma cell | 13 studies | 37% ± 14% | |
endothelial cell | 6 studies | 32% ± 16% | |
microglial cell | 6 studies | 27% ± 13% | |
retina horizontal cell | 5 studies | 25% ± 13% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 20% ± 4% | |
IgA plasma cell | 4 studies | 29% ± 13% | |
IgG plasma cell | 4 studies | 27% ± 8% | |
retinal ganglion cell | 3 studies | 34% ± 6% | |
amacrine cell | 3 studies | 27% ± 10% | |
retinal cone cell | 3 studies | 29% ± 10% | |
epithelial cell | 3 studies | 21% ± 5% | |
GABAergic neuron | 3 studies | 34% ± 7% | |
glutamatergic neuron | 3 studies | 41% ± 11% | |
macrophage | 3 studies | 26% ± 13% | |
astrocyte | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 99% | 1235.86 | 1431 / 1445 | 99% | 8.91 | 182 / 183 |
ovary | 100% | 3013.68 | 180 / 180 | 98% | 8.37 | 420 / 430 |
lung | 98% | 1119.59 | 568 / 578 | 98% | 9.80 | 1128 / 1155 |
uterus | 99% | 1057.39 | 169 / 170 | 94% | 6.49 | 432 / 459 |
breast | 100% | 1586.59 | 459 / 459 | 92% | 5.65 | 1026 / 1118 |
stomach | 98% | 994.99 | 353 / 359 | 93% | 5.40 | 267 / 286 |
intestine | 98% | 1296.56 | 945 / 966 | 93% | 5.54 | 492 / 527 |
bladder | 100% | 1135.52 | 21 / 21 | 89% | 5.90 | 451 / 504 |
prostate | 96% | 997.30 | 236 / 245 | 87% | 3.57 | 439 / 502 |
skin | 100% | 3956.67 | 1808 / 1809 | 83% | 5.27 | 393 / 472 |
kidney | 85% | 918.81 | 76 / 89 | 86% | 11.35 | 778 / 901 |
adrenal gland | 100% | 2184.63 | 258 / 258 | 71% | 4.07 | 164 / 230 |
pancreas | 85% | 632.85 | 278 / 328 | 80% | 3.63 | 142 / 178 |
thymus | 96% | 860.03 | 625 / 653 | 61% | 1.93 | 370 / 605 |
liver | 90% | 1318.65 | 203 / 226 | 59% | 2.69 | 241 / 406 |
brain | 74% | 508.01 | 1945 / 2642 | 60% | 2.87 | 424 / 705 |
spleen | 100% | 2314.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 8.26 | 45 / 45 |
adipose | 100% | 1745.51 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 2019.22 | 1327 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 886.27 | 792 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 2672.34 | 881 / 929 | 0% | 0 | 0 / 0 |
heart | 94% | 2134.66 | 811 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 4.09 | 24 / 29 |
eye | 0% | 0 | 0 / 0 | 19% | 0.71 | 15 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006468 | Biological process | protein phosphorylation |
GO_0010906 | Biological process | regulation of glucose metabolic process |
GO_0008631 | Biological process | intrinsic apoptotic signaling pathway in response to oxidative stress |
GO_0008283 | Biological process | cell population proliferation |
GO_0097411 | Biological process | hypoxia-inducible factor-1alpha signaling pathway |
GO_0010510 | Biological process | regulation of acetyl-CoA biosynthetic process from pyruvate |
GO_0006006 | Biological process | glucose metabolic process |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0004740 | Molecular function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | PDK1 |
Protein name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) Protein-serine/threonine kinase (EC 2.7.11.-) |
Synonyms | PDHK1 |
Description | FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. . |
Accessions | C9IYB4 Q53R49 ENST00000436490.5 ENST00000392571.6 [Q15118-2] ENST00000410055.5 [Q15118-1] ENST00000443353.5 ENST00000431718.5 F8WC75 Q15118 ENST00000416991.5 ENST00000282077.8 [Q15118-1] C9JKT3 F8WEJ6 ENST00000439519.1 |