PDK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0010906Biological processregulation of glucose metabolic process
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0008283Biological processcell population proliferation
GO_0097411Biological processhypoxia-inducible factor-1alpha signaling pathway
GO_0010510Biological processregulation of acetyl-CoA biosynthetic process from pyruvate
GO_0006006Biological processglucose metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004740Molecular functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePDK1
Protein name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Protein-serine/threonine kinase (EC 2.7.11.-)
SynonymsPDHK1
DescriptionFUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. .

AccessionsC9IYB4
Q53R49
ENST00000436490.5
ENST00000392571.6 [Q15118-2]
ENST00000410055.5 [Q15118-1]
ENST00000443353.5
ENST00000431718.5
F8WC75
Q15118
ENST00000416991.5
ENST00000282077.8 [Q15118-1]
C9JKT3
F8WEJ6
ENST00000439519.1