PCSK5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006465Biological processsignal peptide processing
GO_0007507Biological processheart development
GO_0034369Biological processplasma lipoprotein particle remodeling
GO_0030323Biological processrespiratory tube development
GO_0016486Biological processpeptide hormone processing
GO_0048566Biological processembryonic digestive tract development
GO_0016485Biological processprotein processing
GO_0001822Biological processkidney development
GO_0043043Biological processpeptide biosynthetic process
GO_0007267Biological processcell-cell signaling
GO_0002001Biological processrenin secretion into blood stream
GO_0048706Biological processembryonic skeletal system development
GO_0019058Biological processviral life cycle
GO_0035108Biological processlimb morphogenesis
GO_0009952Biological processanterior/posterior pattern specification
GO_0140447Biological processcytokine precursor processing
GO_0007566Biological processembryo implantation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005796Cellular componentGolgi lumen
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0042277Molecular functionpeptide binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePCSK5
Protein nameProprotein convertase subtilisin/kexin type 5
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)
SynonymsPC5
PC6
DescriptionFUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. .

AccessionsI0EZ71
ENST00000376752.9 [Q92824-2]
ENST00000455778.1
Q92824
Q5JSG7
ENST00000424854.6
ENST00000674117.1
A0A669KBD8
ENST00000673745.1
B1AMG8
A0A669KA35
ENST00000545128.5 [Q92824-1]