Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 49% ± 21% | |
endothelial cell | 15 studies | 28% ± 11% | |
fibroblast | 13 studies | 27% ± 8% | |
oligodendrocyte precursor cell | 11 studies | 33% ± 15% | |
adipocyte | 10 studies | 52% ± 15% | |
endothelial cell of artery | 9 studies | 30% ± 12% | |
pericyte | 8 studies | 20% ± 4% | |
GABAergic neuron | 7 studies | 34% ± 14% | |
glutamatergic neuron | 7 studies | 28% ± 8% | |
macrophage | 6 studies | 24% ± 6% | |
retina horizontal cell | 6 studies | 52% ± 27% | |
ciliated cell | 6 studies | 32% ± 12% | |
epithelial cell | 5 studies | 42% ± 20% | |
type I pneumocyte | 5 studies | 22% ± 4% | |
type II pneumocyte | 5 studies | 27% ± 7% | |
interneuron | 4 studies | 49% ± 26% | |
microglial cell | 4 studies | 26% ± 8% | |
enterocyte | 4 studies | 23% ± 6% | |
Mueller cell | 4 studies | 47% ± 19% | |
monocyte | 4 studies | 19% ± 3% | |
smooth muscle cell | 4 studies | 24% ± 4% | |
GABAergic interneuron | 3 studies | 32% ± 15% | |
glial cell | 3 studies | 34% ± 14% | |
granule cell | 3 studies | 43% ± 18% | |
mesothelial cell | 3 studies | 26% ± 7% | |
endothelial cell of vascular tree | 3 studies | 25% ± 6% | |
ependymal cell | 3 studies | 36% ± 23% | |
adventitial cell | 3 studies | 32% ± 10% | |
alveolar macrophage | 3 studies | 28% ± 7% | |
myofibroblast cell | 3 studies | 26% ± 10% | |
neuron | 3 studies | 35% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 1575.12 | 650 / 653 | 97% | 8.68 | 586 / 605 |
esophagus | 100% | 1962.42 | 1445 / 1445 | 95% | 10.79 | 173 / 183 |
lung | 100% | 1847.91 | 577 / 578 | 87% | 4.69 | 1007 / 1155 |
intestine | 100% | 2663.36 | 966 / 966 | 86% | 4.88 | 451 / 527 |
breast | 100% | 2047.19 | 459 / 459 | 82% | 2.76 | 912 / 1118 |
ovary | 100% | 3640.56 | 180 / 180 | 77% | 2.94 | 333 / 430 |
prostate | 98% | 1032.71 | 240 / 245 | 78% | 1.68 | 390 / 502 |
uterus | 100% | 1451.23 | 170 / 170 | 73% | 3.42 | 334 / 459 |
kidney | 90% | 801.76 | 80 / 89 | 82% | 5.61 | 739 / 901 |
pancreas | 74% | 403.56 | 244 / 328 | 92% | 8.94 | 164 / 178 |
bladder | 100% | 1265.14 | 21 / 21 | 60% | 2.10 | 303 / 504 |
adrenal gland | 100% | 771.55 | 257 / 258 | 60% | 2.29 | 139 / 230 |
stomach | 50% | 472.71 | 181 / 359 | 91% | 7.18 | 260 / 286 |
brain | 45% | 218.69 | 1200 / 2642 | 93% | 3.37 | 658 / 705 |
skin | 91% | 882.74 | 1649 / 1809 | 24% | 0.75 | 113 / 472 |
adipose | 100% | 3654.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3151.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
heart | 87% | 794.21 | 745 / 861 | 0% | 0 | 0 / 0 |
liver | 15% | 70.08 | 33 / 226 | 64% | 2.06 | 259 / 406 |
spleen | 63% | 320.98 | 153 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 62% | 2.56 | 28 / 45 |
muscle | 36% | 195.21 | 287 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 21% | 0.27 | 6 / 29 |
peripheral blood | 14% | 63.82 | 128 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 6% | 0.11 | 5 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006465 | Biological process | signal peptide processing |
GO_0007507 | Biological process | heart development |
GO_0034369 | Biological process | plasma lipoprotein particle remodeling |
GO_0030323 | Biological process | respiratory tube development |
GO_0016486 | Biological process | peptide hormone processing |
GO_0048566 | Biological process | embryonic digestive tract development |
GO_0016485 | Biological process | protein processing |
GO_0001822 | Biological process | kidney development |
GO_0043043 | Biological process | peptide biosynthetic process |
GO_0007267 | Biological process | cell-cell signaling |
GO_0002001 | Biological process | renin secretion into blood stream |
GO_0048706 | Biological process | embryonic skeletal system development |
GO_0019058 | Biological process | viral life cycle |
GO_0035108 | Biological process | limb morphogenesis |
GO_0009952 | Biological process | anterior/posterior pattern specification |
GO_0140447 | Biological process | cytokine precursor processing |
GO_0007566 | Biological process | embryo implantation |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005796 | Cellular component | Golgi lumen |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0000139 | Cellular component | Golgi membrane |
GO_0008233 | Molecular function | peptidase activity |
GO_0004175 | Molecular function | endopeptidase activity |
GO_0042277 | Molecular function | peptide binding |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | PCSK5 |
Protein name | Proprotein convertase subtilisin/kexin type 5 Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) |
Synonyms | PC5 PC6 |
Description | FUNCTION: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. . |
Accessions | I0EZ71 ENST00000376752.9 [Q92824-2] ENST00000455778.1 Q92824 Q5JSG7 ENST00000424854.6 ENST00000674117.1 A0A669KBD8 ENST00000673745.1 B1AMG8 A0A669KA35 ENST00000545128.5 [Q92824-1] |