PCLAF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0009411Biological processresponse to UV
GO_0019985Biological processtranslesion synthesis
GO_0006260Biological processDNA replication
GO_0051726Biological processregulation of cell cycle
GO_0007098Biological processcentrosome cycle
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePCLAF
Protein namePCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)
KIAA0101
PCNA-associated factor (PCNA-associated factor of 15 kDa) (PCNA-clamp-associated factor)
SynonymsPAF
hCG_2039386
L5
NS5ATP9
KIAA0101
DescriptionFUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. .

AccessionsQ15004
H0YMA4
ENST00000559519.5
H0YKX3
ENST00000558008.3
G9G6D7
ENST00000300035.9 [Q15004-1]
ENST00000380258.6 [Q15004-2]
G9G6C4
G9G6H1