PASD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PASD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PASD1 at tissue level.

III. Associated gene sets

GO_0042754Biological processnegative regulation of circadian rhythm
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032922Biological processcircadian regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_1990513Cellular componentCLOCK-BMAL transcription complex
GO_1990512Cellular componentCry-Per complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene namePASD1
Protein nameCircadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1)
Synonyms
DescriptionFUNCTION: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body . Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components . Inhibits circadian clock function in cancer cells, when overexpressed . .

AccessionsQ8IV76
ENST00000370357.5 [Q8IV76-1]