PARG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0006282Biological processregulation of DNA repair
GO_0009225Biological processnucleotide-sugar metabolic process
GO_0006287Biological processbase-excision repair, gap-filling
GO_1990966Biological processATP generation from poly-ADP-D-ribose
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004649Molecular functionpoly(ADP-ribose) glycohydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePARG
Protein namepoly(ADP-ribose) glycohydrolase (EC 3.2.1.143)
Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143)
Poly(ADP-ribose) glycohydrolase
Synonyms
DescriptionFUNCTION: Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) . PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers . It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated . Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG . Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress . Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond . Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters . Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming . .

AccessionsQ0MQR4
A0A087WXI6
ENST00000402038.7 [Q86W56-1]
ENST00000610922.1
I1VE11
ENST00000614063.4
A0A087WX07
ENST00000616448.2 [Q86W56-1]
Q6X2S8
Q86W56