PAPPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071548Biological processresponse to dexamethasone
GO_0019538Biological processprotein metabolic process
GO_0032354Biological processresponse to follicle-stimulating hormone
GO_0006508Biological processproteolysis
GO_0007565Biological processfemale pregnancy
GO_0030163Biological processprotein catabolic process
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0008237Molecular functionmetallopeptidase activity

IV. Literature review

[source]
Gene namePAPPA
Protein namePregnacy-associated plasma protein A
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
Synonyms
DescriptionFUNCTION: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. .

AccessionsQ5QFB7
ENST00000328252.4
Q13219