P4HTM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018401Biological processpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO_0045646Biological processregulation of erythrocyte differentiation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005506Molecular functioniron ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0031418Molecular functionL-ascorbic acid binding
GO_0004656Molecular functionprocollagen-proline 4-dioxygenase activity
GO_0160082Molecular functionhypoxia-inducible factor-proline dioxygenase activity
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity

IV. Literature review

[source]
Gene nameP4HTM
Protein nameProlyl 4-hydroxylase, transmembrane
Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)
SynonymsPH4
DescriptionFUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. .

AccessionsV9GYK5
ENST00000472796.2
Q9NXG6
ENST00000383729.9 [Q9NXG6-1]
V9GY20
ENST00000491739.5
ENST00000475629.5
H7C153
ENST00000444213.5
A0A0C4DGS7
ENST00000343546.8 [Q9NXG6-3]