Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 18 studies | 55% ± 19% | |
glutamatergic neuron | 5 studies | 39% ± 24% | |
epithelial cell | 5 studies | 36% ± 16% | |
deuterosomal cell | 4 studies | 30% ± 5% | |
pancreatic A cell | 4 studies | 47% ± 7% | |
type B pancreatic cell | 4 studies | 33% ± 10% | |
neuron | 4 studies | 28% ± 8% | |
retinal ganglion cell | 4 studies | 46% ± 28% | |
type I pneumocyte | 4 studies | 19% ± 3% | |
amacrine cell | 4 studies | 28% ± 12% | |
retina horizontal cell | 4 studies | 35% ± 10% | |
retinal bipolar neuron | 3 studies | 25% ± 7% | |
retinal cone cell | 3 studies | 36% ± 12% | |
fibroblast | 3 studies | 21% ± 3% | |
GABAergic neuron | 3 studies | 41% ± 18% | |
astrocyte | 3 studies | 26% ± 4% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 4% | |
basal cell | 3 studies | 31% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 4851.56 | 2640 / 2642 | 100% | 30.57 | 705 / 705 |
thymus | 100% | 4385.56 | 653 / 653 | 100% | 34.86 | 604 / 605 |
prostate | 100% | 3167.97 | 245 / 245 | 100% | 35.73 | 501 / 502 |
ovary | 100% | 3134.93 | 180 / 180 | 100% | 26.66 | 429 / 430 |
adrenal gland | 100% | 4263.75 | 258 / 258 | 100% | 59.41 | 229 / 230 |
pancreas | 100% | 2675.13 | 328 / 328 | 99% | 24.29 | 177 / 178 |
kidney | 100% | 3202.44 | 89 / 89 | 99% | 18.91 | 891 / 901 |
intestine | 100% | 2225.44 | 966 / 966 | 99% | 20.00 | 520 / 527 |
stomach | 100% | 2474.78 | 359 / 359 | 98% | 16.18 | 279 / 286 |
breast | 100% | 2171.64 | 457 / 459 | 94% | 23.26 | 1049 / 1118 |
bladder | 100% | 1921.43 | 21 / 21 | 92% | 19.36 | 466 / 504 |
lung | 100% | 2475.71 | 576 / 578 | 91% | 13.02 | 1054 / 1155 |
uterus | 100% | 2957.36 | 170 / 170 | 88% | 14.61 | 402 / 459 |
esophagus | 99% | 1518.69 | 1428 / 1445 | 64% | 7.31 | 118 / 183 |
liver | 88% | 842.05 | 200 / 226 | 62% | 7.55 | 250 / 406 |
skin | 99% | 1551.33 | 1799 / 1809 | 42% | 3.94 | 196 / 472 |
spleen | 100% | 2146.49 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 18.33 | 1 / 1 |
blood vessel | 100% | 2231.29 | 1329 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 1723.73 | 1191 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 10.63 | 28 / 29 |
heart | 96% | 1688.91 | 826 / 861 | 0% | 0 | 0 / 0 |
muscle | 85% | 977.77 | 685 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 71% | 8.37 | 32 / 45 |
peripheral blood | 59% | 674.88 | 548 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 5% | 0.57 | 4 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0018401 | Biological process | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
GO_0045646 | Biological process | regulation of erythrocyte differentiation |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005506 | Molecular function | iron ion binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0031418 | Molecular function | L-ascorbic acid binding |
GO_0004656 | Molecular function | procollagen-proline 4-dioxygenase activity |
GO_0160082 | Molecular function | hypoxia-inducible factor-proline dioxygenase activity |
GO_0016706 | Molecular function | 2-oxoglutarate-dependent dioxygenase activity |
Gene name | P4HTM |
Protein name | Prolyl 4-hydroxylase, transmembrane Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) |
Synonyms | PH4 |
Description | FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. . |
Accessions | V9GYK5 ENST00000472796.2 Q9NXG6 ENST00000383729.9 [Q9NXG6-1] V9GY20 ENST00000491739.5 ENST00000475629.5 H7C153 ENST00000444213.5 A0A0C4DGS7 ENST00000343546.8 [Q9NXG6-3] |