P3H2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019511Biological processpeptidyl-proline hydroxylation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032963Biological processcollagen metabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005604Cellular componentbasement membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0005506Molecular functioniron ion binding
GO_0031418Molecular functionL-ascorbic acid binding
GO_0019797Molecular functionprocollagen-proline 3-dioxygenase activity

IV. Literature review

[source]
Gene nameP3H2
Protein nameProlyl 3-hydroxylase 2
Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)
Alternative protein LEPREL1
SynonymsMLAT4
LEPREL1
DescriptionFUNCTION: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens . Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 . Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline . Has no activity on substrates that lack 4-hydroxyproline in the third position . .

AccessionsENST00000444866.5
C9JSL4
ENST00000427335.6 [Q8IVL5-2]
ENST00000426003.1
L8E8F3
C9J313
ENST00000319332.10 [Q8IVL5-1]
Q8IVL5