OTUD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000660Biological processnegative regulation of interleukin-1-mediated signaling pathway
GO_0006307Biological processDNA alkylation repair
GO_0071108Biological processprotein K48-linked deubiquitination
GO_0016579Biological processprotein deubiquitination
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0006508Biological processproteolysis
GO_1903093Biological processregulation of protein K48-linked deubiquitination
GO_0045087Biological processinnate immune response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameOTUD4
Protein nameOTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)
OTUD4 protein
Alternative protein OTUD4
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
SynonymsHIN-1
KIAA1046
DescriptionFUNCTION: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein . May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators . Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions . .

AccessionsENST00000509620.6 [Q01804-4]
L8EAV3
D6RI06
Q01804
A0PJA7
ENST00000447906.8 [Q01804-1]
ENST00000514973.5
D6RA27
ENST00000504501.1
ENST00000454497.6 [Q01804-3]