Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 25% ± 7% | |
ciliated cell | 9 studies | 26% ± 10% | |
oligodendrocyte | 6 studies | 24% ± 7% | |
endothelial cell of vascular tree | 5 studies | 22% ± 7% | |
astrocyte | 5 studies | 26% ± 9% | |
microglial cell | 4 studies | 20% ± 4% | |
epithelial cell | 4 studies | 37% ± 9% | |
fibroblast | 4 studies | 18% ± 2% | |
oligodendrocyte precursor cell | 4 studies | 28% ± 10% | |
macrophage | 4 studies | 21% ± 6% | |
myeloid cell | 3 studies | 18% ± 2% | |
lymphocyte | 3 studies | 19% ± 5% | |
pericyte | 3 studies | 20% ± 4% | |
vein endothelial cell | 3 studies | 29% ± 10% | |
GABAergic neuron | 3 studies | 43% ± 4% | |
glutamatergic neuron | 3 studies | 58% ± 8% | |
type I pneumocyte | 3 studies | 20% ± 5% | |
neuron | 3 studies | 21% ± 7% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 40% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3821.44 | 1445 / 1445 | 100% | 35.53 | 183 / 183 |
lung | 100% | 4867.38 | 578 / 578 | 100% | 19.69 | 1155 / 1155 |
ovary | 100% | 3765.79 | 180 / 180 | 100% | 18.79 | 430 / 430 |
breast | 100% | 3765.41 | 459 / 459 | 99% | 21.52 | 1106 / 1118 |
pancreas | 100% | 2220.69 | 328 / 328 | 99% | 16.85 | 176 / 178 |
intestine | 100% | 3604.89 | 966 / 966 | 99% | 17.61 | 520 / 527 |
bladder | 100% | 3534.05 | 21 / 21 | 99% | 16.53 | 497 / 504 |
kidney | 100% | 2567.07 | 89 / 89 | 99% | 17.81 | 888 / 901 |
uterus | 100% | 4296.46 | 170 / 170 | 98% | 18.83 | 452 / 459 |
brain | 99% | 2497.03 | 2604 / 2642 | 100% | 14.47 | 703 / 705 |
stomach | 100% | 2637.34 | 359 / 359 | 98% | 19.44 | 280 / 286 |
thymus | 100% | 4092.06 | 653 / 653 | 98% | 15.93 | 592 / 605 |
prostate | 100% | 3178.77 | 245 / 245 | 97% | 12.77 | 488 / 502 |
skin | 100% | 4285.95 | 1808 / 1809 | 96% | 18.54 | 453 / 472 |
adrenal gland | 100% | 3219.62 | 258 / 258 | 95% | 10.54 | 219 / 230 |
liver | 100% | 2638.12 | 226 / 226 | 85% | 7.56 | 346 / 406 |
adipose | 100% | 4015.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3797.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 6469.81 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3744.39 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.85 | 1 / 1 |
heart | 98% | 2236.18 | 844 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 13.33 | 28 / 29 |
tonsil | 0% | 0 | 0 / 0 | 96% | 22.22 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 91% | 10.61 | 73 / 80 |
peripheral blood | 47% | 1226.17 | 440 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000660 | Biological process | negative regulation of interleukin-1-mediated signaling pathway |
GO_0006307 | Biological process | DNA alkylation repair |
GO_0071108 | Biological process | protein K48-linked deubiquitination |
GO_0016579 | Biological process | protein deubiquitination |
GO_0070536 | Biological process | protein K63-linked deubiquitination |
GO_0034122 | Biological process | negative regulation of toll-like receptor signaling pathway |
GO_0006508 | Biological process | proteolysis |
GO_1903093 | Biological process | regulation of protein K48-linked deubiquitination |
GO_0045087 | Biological process | innate immune response |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0061578 | Molecular function | K63-linked deubiquitinase activity |
GO_0003723 | Molecular function | RNA binding |
Gene name | OTUD4 |
Protein name | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) OTUD4 protein Alternative protein OTUD4 ubiquitinyl hydrolase 1 (EC 3.4.19.12) |
Synonyms | HIN-1 KIAA1046 |
Description | FUNCTION: Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein . May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators . Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions . . |
Accessions | ENST00000509620.6 [Q01804-4] L8EAV3 D6RI06 Q01804 A0PJA7 ENST00000447906.8 [Q01804-1] ENST00000514973.5 D6RA27 ENST00000504501.1 ENST00000454497.6 [Q01804-3] |