ORC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ORC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ORC1 at tissue level.

III. Associated gene sets

GO_0033314Biological processmitotic DNA replication checkpoint signaling
GO_0006270Biological processDNA replication initiation
GO_0000808Cellular componentorigin recognition complex
GO_0005664Cellular componentnuclear origin of replication recognition complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003688Molecular functionDNA replication origin binding
GO_0046872Molecular functionmetal ion binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameORC1
Protein nameOrigin recognition complex subunit 1 (Replication control protein 1)
SynonymsORC1L
PARC1
DescriptionFUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

AccessionsENST00000371568.8
Q13415
ENST00000371566.1