NUP153 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046832Biological processnegative regulation of RNA export from nucleus
GO_0006405Biological processRNA export from nucleus
GO_0051028Biological processmRNA transport
GO_0051292Biological processnuclear pore complex assembly
GO_1990000Biological processamyloid fibril formation
GO_0046718Biological processsymbiont entry into host cell
GO_0006606Biological processprotein import into nucleus
GO_0006913Biological processnucleocytoplasmic transport
GO_0075732Biological processviral penetration into host nucleus
GO_0042405Cellular componentnuclear inclusion body
GO_0005730Cellular componentnucleolus
GO_0005643Cellular componentnuclear pore
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005829Cellular componentcytosol
GO_0043657Cellular componenthost cell
GO_0031965Cellular componentnuclear membrane
GO_0034399Cellular componentnuclear periphery
GO_0003677Molecular functionDNA binding
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0008139Molecular functionnuclear localization sequence binding
GO_0017056Molecular functionstructural constituent of nuclear pore
GO_0042802Molecular functionidentical protein binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUP153
Protein nameNuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)
Synonyms
DescriptionFUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). .; FUNCTION: (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). .; FUNCTION: (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). .

AccessionsENST00000537253.5 [P49790-3]
P49790
ENST00000613258.4 [P49790-2]
ENST00000262077.3 [P49790-1]