NUMBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007409Biological processaxonogenesis
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0050769Biological processpositive regulation of neurogenesis
GO_0034332Biological processadherens junction organization
GO_0021849Biological processneuroblast division in subventricular zone
GO_0021670Biological processlateral ventricle development
GO_0007399Biological processnervous system development
GO_0019538Biological processprotein metabolic process
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUMBL
Protein nameNumb homolog (Drosophila)-like
Numb-like protein
Numb-like protein (Numb-related protein) (Numb-R)
NUMB like endocytic adaptor protein
SynonymshCG_20792
DescriptionFUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. .

FUNCTION: Plays a role in the process of neurogenesis. .

FUNCTION: Plays a role in the process of neurogenesis. .

AccessionsA0A0C4DGH3
M0QZV7
ENST00000598779.5
M0QYC2
ENST00000598773.5
ENST00000540131.5
M0R0Q4
M0QXQ4
Q9Y6R0
A8K033
ENST00000600967.5
ENST00000595741.5
ENST00000600636.5
ENST00000252891.8