NUDT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901909Biological processdiadenosine hexaphosphate catabolic process
GO_0110154Biological processRNA decapping
GO_0071544Biological processdiphosphoinositol polyphosphate catabolic process
GO_0015961Biological processdiadenosine polyphosphate catabolic process
GO_0007267Biological processcell-cell signaling
GO_1901911Biological processadenosine 5'-(hexahydrogen pentaphosphate) catabolic process
GO_0071543Biological processdiphosphoinositol polyphosphate metabolic process
GO_1901907Biological processdiadenosine pentaphosphate catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0052848Molecular functioninositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO_0034431Molecular functionbis(5'-adenosyl)-hexaphosphatase activity
GO_0140932Molecular function5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
GO_0034432Molecular functionbis(5'-adenosyl)-pentaphosphatase activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0008486Molecular functiondiphosphoinositol-polyphosphate diphosphatase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030145Molecular functionmanganese ion binding
GO_0052840Molecular functioninositol diphosphate tetrakisphosphate diphosphatase activity
GO_0052842Molecular functioninositol diphosphate pentakisphosphate diphosphatase activity
GO_0008270Molecular functionzinc ion binding
GO_0052845Molecular functioninositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO_0000298Molecular functionendopolyphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUDT3
Protein nameDiphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59)
SynonymsDIPP
DIPP1
DescriptionFUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . InsP6 (inositol hexakisphosphate) is not a substrate . Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates . The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility . Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA . Can hydrolyze unmethylated capped RNAs (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity . Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions . Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity . .

AccessionsO95989
ENST00000607016.2