Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 26% ± 11% | |
macrophage | 15 studies | 22% ± 8% | |
conventional dendritic cell | 9 studies | 24% ± 9% | |
glutamatergic neuron | 9 studies | 37% ± 22% | |
microglial cell | 8 studies | 34% ± 16% | |
astrocyte | 8 studies | 33% ± 14% | |
fibroblast | 7 studies | 20% ± 4% | |
classical monocyte | 6 studies | 27% ± 8% | |
neuron | 6 studies | 38% ± 15% | |
amacrine cell | 6 studies | 27% ± 9% | |
myeloid cell | 6 studies | 27% ± 13% | |
ciliated cell | 5 studies | 31% ± 13% | |
B cell | 5 studies | 21% ± 3% | |
retinal ganglion cell | 5 studies | 71% ± 24% | |
GABAergic neuron | 5 studies | 42% ± 18% | |
hematopoietic precursor cell | 4 studies | 26% ± 12% | |
non-classical monocyte | 4 studies | 31% ± 12% | |
capillary endothelial cell | 4 studies | 17% ± 1% | |
retinal bipolar neuron | 4 studies | 23% ± 1% | |
epithelial cell | 4 studies | 38% ± 18% | |
retina horizontal cell | 4 studies | 29% ± 12% | |
retinal cone cell | 4 studies | 23% ± 4% | |
monocyte | 4 studies | 24% ± 4% | |
enteroendocrine cell | 4 studies | 22% ± 7% | |
interneuron | 4 studies | 45% ± 16% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 8% | |
smooth muscle cell | 3 studies | 24% ± 9% | |
mononuclear phagocyte | 3 studies | 29% ± 16% | |
abnormal cell | 3 studies | 19% ± 1% | |
naive B cell | 3 studies | 20% ± 2% | |
myofibroblast cell | 3 studies | 26% ± 5% | |
Mueller cell | 3 studies | 31% ± 9% | |
basal cell | 3 studies | 22% ± 8% | |
dendritic cell | 3 studies | 39% ± 17% | |
plasmacytoid dendritic cell | 3 studies | 19% ± 1% | |
oligodendrocyte | 3 studies | 28% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 3638.49 | 180 / 180 | 83% | 1.61 | 358 / 430 |
esophagus | 100% | 3290.07 | 1444 / 1445 | 54% | 0.83 | 99 / 183 |
stomach | 99% | 2118.99 | 354 / 359 | 46% | 0.83 | 132 / 286 |
intestine | 100% | 3508.60 | 965 / 966 | 31% | 0.52 | 161 / 527 |
bladder | 100% | 3608.19 | 21 / 21 | 8% | 0.13 | 41 / 504 |
lung | 99% | 3468.96 | 575 / 578 | 8% | 0.13 | 90 / 1155 |
thymus | 100% | 4739.06 | 653 / 653 | 6% | 0.10 | 37 / 605 |
skin | 100% | 3122.50 | 1800 / 1809 | 7% | 0.08 | 31 / 472 |
brain | 100% | 9299.83 | 2642 / 2642 | 5% | 0.08 | 36 / 705 |
uterus | 100% | 3703.11 | 170 / 170 | 3% | 0.05 | 13 / 459 |
breast | 100% | 3316.23 | 459 / 459 | 1% | 0.01 | 10 / 1118 |
adrenal gland | 100% | 3302.95 | 258 / 258 | 0% | 0.01 | 1 / 230 |
kidney | 100% | 3049.30 | 89 / 89 | 0% | 0.00 | 3 / 901 |
muscle | 100% | 7381.24 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3104.32 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 3356.95 | 1203 / 1204 | 0% | 0 | 0 / 0 |
prostate | 100% | 3282.89 | 244 / 245 | 0% | 0.00 | 1 / 502 |
blood vessel | 100% | 3859.63 | 1331 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 3420.27 | 822 / 861 | 0% | 0 | 0 / 0 |
pancreas | 94% | 1699.81 | 309 / 328 | 0% | 0 | 0 / 178 |
liver | 94% | 1540.15 | 212 / 226 | 0% | 0.00 | 1 / 406 |
peripheral blood | 77% | 2263.53 | 711 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 5% | 0.07 | 4 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1901909 | Biological process | diadenosine hexaphosphate catabolic process |
GO_0110154 | Biological process | RNA decapping |
GO_0071544 | Biological process | diphosphoinositol polyphosphate catabolic process |
GO_0015961 | Biological process | diadenosine polyphosphate catabolic process |
GO_0007267 | Biological process | cell-cell signaling |
GO_1901911 | Biological process | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
GO_0071543 | Biological process | diphosphoinositol polyphosphate metabolic process |
GO_1901907 | Biological process | diadenosine pentaphosphate catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0052848 | Molecular function | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
GO_0034431 | Molecular function | bis(5'-adenosyl)-hexaphosphatase activity |
GO_0140932 | Molecular function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
GO_0034432 | Molecular function | bis(5'-adenosyl)-pentaphosphatase activity |
GO_0140933 | Molecular function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
GO_0008486 | Molecular function | diphosphoinositol-polyphosphate diphosphatase activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0030145 | Molecular function | manganese ion binding |
GO_0052840 | Molecular function | inositol diphosphate tetrakisphosphate diphosphatase activity |
GO_0052842 | Molecular function | inositol diphosphate pentakisphosphate diphosphatase activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0052845 | Molecular function | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
GO_0000298 | Molecular function | endopolyphosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NUDT3 |
Protein name | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) |
Synonyms | DIPP DIPP1 |
Description | FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction . InsP6 (inositol hexakisphosphate) is not a substrate . Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates . The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A . Also able to hydrolyze 5-phosphoribose 1-diphosphate . Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility . Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA . Can hydrolyze unmethylated capped RNAs (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity . Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions . Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity . . |
Accessions | O95989 ENST00000607016.2 |