NSMCE4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006974Biological processDNA damage response
GO_0016925Biological processprotein sumoylation
GO_0006281Biological processDNA repair
GO_0032204Biological processregulation of telomere maintenance
GO_0140588Biological processchromatin looping
GO_0030915Cellular componentSmc5-Smc6 complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNSMCE4A
Protein nameNon-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A)
SynonymsC10orf86
PP4762
DescriptionFUNCTION: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. .

AccessionsQ9NXX6
ENST00000369017.5 [Q9NXX6-2]
ENST00000369023.8 [Q9NXX6-1]