NSFL1C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	11 studies	25% ± 8%	Explore
ciliated cell	9 studies	28% ± 9%	Explore
B cell	8 studies	18% ± 4%	Explore
naive B cell	8 studies	17% ± 2%	Explore
fibroblast	7 studies	23% ± 7%	Explore
epithelial cell	7 studies	36% ± 16%	Explore
basal cell	7 studies	23% ± 9%	Explore
classical monocyte	6 studies	24% ± 9%	Explore
pericyte	6 studies	19% ± 4%	Explore
abnormal cell	6 studies	24% ± 7%	Explore
neuron	5 studies	32% ± 12%	Explore
smooth muscle cell	5 studies	24% ± 5%	Explore
regulatory T cell	5 studies	18% ± 1%	Explore
macrophage	5 studies	24% ± 5%	Explore
natural killer cell	5 studies	17% ± 1%	Explore
memory B cell	5 studies	16% ± 1%	Explore
non-classical monocyte	4 studies	26% ± 8%	Explore
glutamatergic neuron	4 studies	38% ± 19%	Explore
CD8-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
goblet cell	4 studies	19% ± 3%	Explore
plasmacytoid dendritic cell	4 studies	22% ± 5%	Explore
pancreatic A cell	3 studies	31% ± 1%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
conventional dendritic cell	3 studies	37% ± 11%	Explore
hematopoietic precursor cell	3 studies	25% ± 7%	Explore
connective tissue cell	3 studies	22% ± 5%	Explore
myofibroblast cell	3 studies	21% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	15% ± 0%	Explore
precursor B cell	3 studies	20% ± 3%	Explore
amacrine cell	3 studies	36% ± 13%	Explore
astrocyte	3 studies	25% ± 5%	Explore
retina horizontal cell	3 studies	27% ± 12%	Explore
retinal pigment epithelial cell	3 studies	34% ± 18%	Explore
endothelial cell of vascular tree	3 studies	17% ± 2%	Explore
GABAergic neuron	3 studies	37% ± 13%	Explore
dendritic cell	3 studies	38% ± 15%	Explore
pancreatic ductal cell	3 studies	40% ± 16%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 1%	Explore
enteroendocrine cell	3 studies	25% ± 8%	Explore
monocyte	3 studies	16% ± 1%	Explore
oligodendrocyte	3 studies	23% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	23% ± 6%	Explore
brain	5 studies	29% ± 10%	Explore
peripheral blood	4 studies	21% ± 4%	Explore
pancreas	3 studies	30% ± 5%	Explore
eye	3 studies	25% ± 9%	Explore
intestine	3 studies	23% ± 8%	Explore
liver	3 studies	29% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4786.92	1445 / 1445	100%	39.26	183 / 183
kidney	100%	3823.01	89 / 89	100%	40.94	901 / 901
liver	100%	2841.59	226 / 226	100%	36.10	406 / 406
ovary	100%	4447.41	180 / 180	100%	39.87	430 / 430
prostate	100%	4289.66	245 / 245	100%	40.99	502 / 502
skin	100%	5859.48	1809 / 1809	100%	47.87	472 / 472
stomach	100%	3167.40	359 / 359	100%	38.14	286 / 286
thymus	100%	3718.34	653 / 653	100%	46.12	605 / 605
uterus	100%	4849.51	170 / 170	100%	59.11	459 / 459
brain	100%	4852.06	2641 / 2642	100%	51.31	705 / 705
intestine	100%	4375.17	966 / 966	100%	40.54	526 / 527
bladder	100%	4847.76	21 / 21	100%	55.00	503 / 504
lung	100%	4247.05	578 / 578	100%	46.02	1152 / 1155
breast	100%	4562.94	459 / 459	100%	46.91	1114 / 1118
adrenal gland	100%	7645.55	258 / 258	99%	43.68	228 / 230
pancreas	99%	1852.41	325 / 328	100%	40.09	178 / 178
adipose	100%	4690.31	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4927.11	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	40.10	80 / 80
lymph node	0%	0	0 / 0	100%	43.35	29 / 29
muscle	100%	6951.00	803 / 803	0%	0	0 / 0
spleen	100%	5435.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	56.50	45 / 45
ureter	0%	0	0 / 0	100%	35.61	1 / 1
peripheral blood	99%	5956.44	921 / 929	0%	0	0 / 0
heart	99%	3318.11	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1904780	Biological process	negative regulation of protein localization to centrosome
GO_0000045	Biological process	autophagosome assembly
GO_0061025	Biological process	membrane fusion
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0000132	Biological process	establishment of mitotic spindle orientation
GO_0007030	Biological process	Golgi organization
GO_0046604	Biological process	positive regulation of mitotic centrosome separation
GO_0031468	Biological process	nuclear membrane reassembly
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005795	Cellular component	Golgi stack
GO_0005813	Cellular component	centrosome
GO_1990730	Cellular component	VCP-NSFL1C complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005694	Cellular component	chromosome
GO_0005634	Cellular component	nucleus
GO_0008289	Molecular function	lipid binding
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	NSFL1C
Protein name	NSFL1 cofactor Alternative protein NSFL1C NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)
Synonyms	UBXN2C
Description	FUNCTION: Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) . Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase . Also, regulates spindle orientation during mitosis . .
Accessions	ENST00000381653.9 L8EBH2 ENST00000489203.2 G3V4V8 R4GNE6 ENST00000555568.5 ENST00000353088.6 [Q9UNZ2-4] ENST00000555944.5 ENST00000216879.9 [Q9UNZ2-1] F2Z2K0 R4GMY2 ENST00000470376.5 ENST00000476071.5 [Q9UNZ2-5] Q9UNZ2

NSFL1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review