NSDHL | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	27% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of NSDHL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1741.29	226 / 226	100%	63.10	406 / 406
ovary	100%	781.84	180 / 180	100%	46.98	430 / 430
skin	100%	1602.66	1809 / 1809	100%	48.46	472 / 472
uterus	100%	1004.82	170 / 170	100%	75.56	459 / 459
stomach	100%	853.56	358 / 359	100%	56.49	286 / 286
prostate	100%	974.18	245 / 245	100%	44.69	500 / 502
thymus	100%	1147.37	652 / 653	100%	43.54	603 / 605
intestine	100%	1075.03	964 / 966	100%	67.41	525 / 527
esophagus	100%	1740.98	1443 / 1445	99%	47.68	182 / 183
breast	100%	1587.94	459 / 459	99%	55.34	1110 / 1118
bladder	100%	821.43	21 / 21	99%	64.65	500 / 504
kidney	100%	860.45	89 / 89	99%	33.62	893 / 901
lung	99%	1057.18	573 / 578	100%	57.41	1151 / 1155
adrenal gland	100%	2802.16	258 / 258	99%	80.42	227 / 230
brain	98%	778.70	2600 / 2642	100%	50.30	705 / 705
pancreas	93%	479.13	305 / 328	99%	45.36	177 / 178
adipose	100%	1746.30	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	34.85	80 / 80
lymph node	0%	0	0 / 0	100%	52.79	29 / 29
spleen	100%	732.36	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	81.20	45 / 45
ureter	0%	0	0 / 0	100%	56.91	1 / 1
blood vessel	100%	739.02	1329 / 1335	0%	0	0 / 0
muscle	95%	459.00	759 / 803	0%	0	0 / 0
heart	94%	1128.20	809 / 861	0%	0	0 / 0
peripheral blood	73%	575.35	681 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0008203	Biological process	cholesterol metabolic process
GO_0007224	Biological process	smoothened signaling pathway
GO_0006695	Biological process	cholesterol biosynthetic process
GO_0060716	Biological process	labyrinthine layer blood vessel development
GO_0001942	Biological process	hair follicle development
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005811	Cellular component	lipid droplet
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0102175	Molecular function	3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity
GO_0103066	Molecular function	4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity
GO_0000252	Molecular function	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
GO_0003854	Molecular function	3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
GO_0047012	Molecular function	sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO_0005515	Molecular function	protein binding
GO_0016616	Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO_0103067	Molecular function	4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity

Gene name	NSDHL
Protein name	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3) NAD(P) dependent steroid dehydrogenase-like
Synonyms	H105E3
Description	FUNCTION: Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity). .
Accessions	ENST00000709998.1 ENST00000710000.1 Q15738 C9JDR0 ENST00000432467.1 ENST00000370274.8 ENST00000440023.5

NSDHL report