I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 41% ± 17% | |
| ciliated cell | 4 studies | 28% ± 10% | |
| GABAergic neuron | 3 studies | 40% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 41% ± 17% | |
| ciliated cell | 4 studies | 28% ± 10% | |
| GABAergic neuron | 3 studies | 40% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 30% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 97% | 270.28 | 238 / 245 | 60% | 3.18 | 300 / 502 |
| pancreas | 100% | 828.57 | 328 / 328 | 42% | 0.98 | 75 / 178 |
| lung | 88% | 85.28 | 511 / 578 | 36% | 1.16 | 414 / 1155 |
| bladder | 76% | 105.62 | 16 / 21 | 43% | 1.40 | 215 / 504 |
| adrenal gland | 98% | 160.93 | 254 / 258 | 17% | 0.46 | 38 / 230 |
| ovary | 56% | 31.84 | 100 / 180 | 55% | 1.86 | 238 / 430 |
| kidney | 89% | 59.53 | 79 / 89 | 13% | 0.52 | 114 / 901 |
| esophagus | 62% | 50.02 | 899 / 1445 | 39% | 1.19 | 71 / 183 |
| liver | 83% | 64.80 | 188 / 226 | 18% | 0.39 | 72 / 406 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.13 | 1 / 1 |
| stomach | 83% | 198.37 | 299 / 359 | 13% | 0.37 | 38 / 286 |
| uterus | 58% | 41.31 | 99 / 170 | 37% | 1.37 | 172 / 459 |
| muscle | 95% | 191.07 | 765 / 803 | 0% | 0 | 0 / 0 |
| brain | 89% | 297.80 | 2358 / 2642 | 6% | 0.11 | 40 / 705 |
| spleen | 90% | 57.39 | 217 / 241 | 0% | 0 | 0 / 0 |
| skin | 85% | 101.28 | 1531 / 1809 | 2% | 0.05 | 8 / 472 |
| thymus | 74% | 45.40 | 480 / 653 | 2% | 0.04 | 10 / 605 |
| intestine | 65% | 41.67 | 629 / 966 | 9% | 0.28 | 46 / 527 |
| breast | 54% | 31.45 | 250 / 459 | 3% | 0.09 | 38 / 1118 |
| adipose | 50% | 32.67 | 601 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 31% | 14.50 | 416 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 0.41 | 11 / 45 |
| peripheral blood | 19% | 16.72 | 178 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.50 | 3 / 29 |
| heart | 8% | 4.26 | 72 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0038138 | Biological process | ERBB4-ERBB4 signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0048018 | Molecular function | receptor ligand activity |
| Gene name | NRG4 |
| Protein name | Neuregulin 4 Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)] |
| Synonyms | hCG_38309 DKFZp779N1944 |
| Description | FUNCTION: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). . |
| Accessions | Q0P6N4 ENST00000567126.5 ENST00000563204.5 H3BP63 ENST00000568073.5 ENST00000565661.5 E9PJI7 ENST00000461391.5 Q7Z663 Q0P6N6 ENST00000472094.5 ENST00000498750.5 Q0P6N5 ENST00000394907.8 ENST00000567936.5 ENST00000562114.5 Q8WWG1 ENST00000563910.5 ENST00000566417.5 |
