NPTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902683Biological processregulation of receptor localization to synapse
GO_0045743Biological processpositive regulation of fibroblast growth factor receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0048170Biological processpositive regulation of long-term neuronal synaptic plasticity
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_1904861Biological processexcitatory synapse assembly
GO_0060291Biological processlong-term synaptic potentiation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0001818Biological processnegative regulation of cytokine production
GO_0001772Cellular componentimmunological synapse
GO_0009986Cellular componentcell surface
GO_0014069Cellular componentpostsynaptic density
GO_0042734Cellular componentpresynaptic membrane
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005105Molecular functiontype 1 fibroblast growth factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNPTN
Protein nameNeuroplastin
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)
SynonymsDKFZp566H1924
SDR1
SDFR1
DescriptionFUNCTION: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity . Promotes localization of XKR8 at the cell membrane . .

AccessionsENST00000563691.5 [Q9Y639-5]
H3BQ94
H3BU51
ENST00000567198.1
ENST00000351217.10 [Q9Y639-1]
Q9Y639
ENST00000565282.5
ENST00000565325.5
ENST00000345330.9 [Q9Y639-2]
ENST00000562924.5 [Q9Y639-3]
Q9UFM8