NPRL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NPRL2 at tissue level.

III. Associated gene sets

GO_0033673Biological processnegative regulation of kinase activity
GO_0010508Biological processpositive regulation of autophagy
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_1990130Cellular componentGATOR1 complex
GO_0005774Cellular componentvacuolar membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameNPRL2
Protein nameGATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)
NPR2 like, GATOR1 complex subunit
SynonymsTUSC4
DescriptionFUNCTION: Catalytic component of the GATOR1 complex, a multiprotein complex that functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway . In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling . In the presence of abundant amino acids, the GATOR1 complex is ubiquitinated and inhibited by GATOR2 . Within the GATOR1 complex, NPRL2 constitutes the catalytic subunit that mediates the GTPase activator activity and under methionine-sufficient conditions, the GTPase activator activity is inhibited by PRMT1 through methylation and consequently inducing timely mTORC1 activation . .; FUNCTION: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling . Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues . May act as a tumor suppressor . Suppresses cell growth and enhances sensitivity to various anticancer drugs . .

AccessionsA0A590UJY0
ENST00000448302.1
ENST00000433999.5
F2Z2R8
Q8WTW4
ENST00000429366.5
ENST00000418825.5
ENST00000451194.5
ENST00000433381.5
F2Z3D4
ENST00000667046.1
ENST00000232501.8 [Q8WTW4-1]