NOVA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0030182Biological processneuron differentiation
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0051252Biological processregulation of RNA metabolic process
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_1902667Biological processregulation of axon guidance
GO_0021954Biological processcentral nervous system neuron development
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990825Molecular functionsequence-specific mRNA binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOVA2
Protein nameNOVA alternative splicing regulator 2 (Neuro-oncological ventral antigen 2)
NOVA alternative splicing regulator 2
NOVA2 [amino acids 1-28]
RNA-binding protein Nova-2 (Astrocytic NOVA1-like RNA-binding protein) (Neuro-oncological ventral antigen 2)
SynonymshCG_20810
ANOVA
NOVA3
DescriptionFUNCTION: Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion . It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons . Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 snRNP binding and exon inclusion, whereas binding to an intronic 5'-YCAY-3' cluster enhances spliceosome assembly and exon inclusion. With NOVA1, they perform unique biological functions in different brain areas and cell types. Uniquely regulates alternative splicing events of a series of axon guidance related genes during cortical development, being essential for central nervous system development by regulating neural networks wiring. Regulates differentially alternative splicing on the same transcripts expressed in different neurons. This includes functional differences in transcripts expressed in cortical and cerebellar excitatory versus inhibitory neurons where is required for, respectively, development of laminar structure and motor coordination and synapse formation. Also the regulation the regulation of intron retention can sequester the trans-acting splicing factor PTBP2, acting as a variable cis-acting scaffolding platform for PTBP2 across various natural conditions (By similarity). .

AccessionsENST00000596784.1
Q9UNW9
A0A6Q8PFC2
ENST00000676183.1
M0R1A0
ENST00000263257.6
Q9HDB7