NOL9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000448Biological processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0000460Biological processmaturation of 5.8S rRNA
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0046404Molecular functionATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO_0005515Molecular functionprotein binding
GO_0051731Molecular functionpolynucleotide 5'-hydroxyl-kinase activity
GO_0051736Molecular functionATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNOL9
Protein namePolynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.78) (Nucleolar protein 9)
Synonyms
DescriptionFUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates . Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form . Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) . Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus . .

AccessionsENST00000377705.6
Q5SY16