NME5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009116Biological processnucleoside metabolic process
GO_0060271Biological processcilium assembly
GO_0007283Biological processspermatogenesis
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0006228Biological processUTP biosynthetic process
GO_0051649Biological processestablishment of localization in cell
GO_0003351Biological processepithelial cilium movement involved in extracellular fluid movement
GO_0021591Biological processventricular system development
GO_0006183Biological processGTP biosynthetic process
GO_0003341Biological processcilium movement
GO_0007286Biological processspermatid development
GO_0006241Biological processCTP biosynthetic process
GO_0005575Cellular componentcellular_component
GO_0036126Cellular componentsperm flagellum
GO_0005576Cellular componentextracellular region
GO_0097729Cellular component9+2 motile cilium
GO_0001534Cellular componentradial spoke
GO_0005929Cellular componentcilium
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0008408Molecular function3'-5' exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNME5
Protein nameNucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (3'-5' exonuclease NME5) (EC 3.1.-.-) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5)
Non-metastatic cells 5 protein expressed in isoform 3
Non-metastatic cells 5 protein expressed in isoform 1
Synonyms
DescriptionFUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Does not seem to have nucleoside diphosphate kinase (NDPK) activity . Confers protection from cell death by BAX and alters the cellular levels of several antioxidant enzymes including GPX5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair . .

AccessionsP56597
A0A0S2Z4L9
ENST00000265191.4
A0A0S2Z4M0