NKIRAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032484Biological processRal protein signal transduction
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0043129Biological processsurfactant homeostasis
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0048286Biological processlung alveolus development
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005525Molecular functionGTP binding
GO_0032794Molecular functionGTPase activating protein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameNKIRAS1
Protein nameNF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1)
NFKB inhibitor interacting Ras like 1 (NFKB inhibitor interacting Ras-like 1, isoform CRA_a)
SynonymsKBRAS1
hCG_1778083
DescriptionFUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. .

AccessionsENST00000412028.5
G5E9P3
ENST00000388759.7
ENST00000437230.5
Q9NYS0
ENST00000415901.6
ENST00000421515.6
ENST00000614374.4
ENST00000443659.6
ENST00000416026.2
ENST00000425478.7