NINJ2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NINJ2 at tissue level.

III. Associated gene sets

GO_0007155Biological processcell adhesion
GO_0007158Biological processneuron cell-cell adhesion
GO_0042246Biological processtissue regeneration
GO_0007399Biological processnervous system development
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNINJ2
Protein nameNinjurin-2 (Nerve injury-induced protein 2)
Ninjurin 2
Ninjurin 2 (cDNA FLJ52244, weakly similar to Ninjurin-2)
SynonymshCG_25274
DescriptionFUNCTION: Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) (By similarity). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in nerve regeneration . Promotes axonal growth . .

AccessionsENST00000397265.7
ENST00000433832.2
F5H3L1
ENST00000305108.10
A0A590UJR9
F8WBZ3
Q9NZG7
ENST00000662884.1
B4DNS9
ENST00000542920.1